Journal article
African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans
Investigative ophthalmology & visual science, v 56(6), pp 3999-4005
01 Jun 2015
PMID: 26098467
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To examine the relationship between proportion of African ancestry (PAA) and proliferative diabetic retinopathy (PDR) and to identify genetic loci associated with PDR using admixture mapping in African Americans with type 2 diabetes (T2D).
Between 1993 and 2013, 1440 participants enrolled in four different studies had fundus photographs graded using the Early Treatment Diabetic Retinopathy Study scale. Cases (n = 305) had PDR while controls (n = 1135) had nonproliferative diabetic retinopathy (DR) or no DR. Covariates included diabetes duration, hemoglobin A1C, systolic blood pressure, income, and education. Genotyping was performed on the Affymetrix platform. The association between PAA and PDR was evaluated using logistic regression. Genome-wide admixture scanning was performed using ANCESTRYMAP software.
In the univariate analysis, PDR was associated with increased PAA (odds ratio [OR] = 1.36, 95% confidence interval [CI] = 1.16-1.59, P = 0.0002). In multivariate regression adjusting for traditional DR risk factors, income and education, the association between PAA and PDR was attenuated and no longer significant (OR = 1.21, 95% CI = 0.59-2.47, P = 0.61). For the admixture analyses, the maximum genome-wide score was 1.44 on chromosome 1.
In this largest study of PDR in African Americans with T2D to date, an association between PAA and PDR is not present after adjustment for clinical, demographic, and socioeconomic factors. No genome-wide significant locus (defined as having a locus-genome statistic > 5) was identified with admixture analysis. Further analyses with even larger sample sizes are needed to definitively assess if any admixture signal for DR is present.
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Details
- Title
- African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans
- Creators
- Arti Tandon - Harvard UniversityChing J Chen - University of Mississippi Medical CenterAlan Penman - University of Mississippi Medical CenterHeather Hancock - University of Mississippi Medical CenterMaurice James - Jackson Memorial HospitalDeeba Husain - Massachusetts Eye and Ear InfirmaryChristopher Andreoli - Harvard Vanguard Medical AssociatesXiaohui Li - Genomics (United Kingdom)Jane Z Kuo - Pathway Genomics (United States)Omolola Idowu - University of Mississippi Medical CenterDaniel Riche - University of Mississippi Medical CenterEvangelia Papavasilieou - Massachusetts Eye and Ear InfirmaryStacey Brauner - Massachusetts Eye and Ear InfirmarySataria O Smith - University of Mississippi Medical CenterSuzanne Hoadley - University of Mississippi Medical CenterCole Richardson - University of Mississippi Medical CenterTroy Kieser - Harvard Vanguard Medical AssociatesVanessa Vazquez - Boston Medical CenterCheryl Chi - Boston Medical CenterMarlene Fernandez - Center for Human GeneticsMaegan Harden - Broad InstituteMary Frances Cotch - National Eye InstituteDavid Siscovick - University of WashingtonHerman A Taylor - University of Mississippi Medical CenterJames G Wilson - University of Mississippi Medical CenterDavid Reich - Broad InstituteTien Y Wong - National University of SingaporeRonald Klein - University of Wisconsin School of Medicine and Public HealthBarbara E K Klein - University of Wisconsin School of Medicine and Public HealthJerome I Rotter - Genomics (United Kingdom)Nick Patterson - Broad InstituteLucia Sobrin - Massachusetts Eye and Ear Infirmary
- Publication Details
- Investigative ophthalmology & visual science, v 56(6), pp 3999-4005
- Publisher
- ARVO
- Grant note
- Z01 EY000426-04 / Intramural NIH HHS Z01 EY000425-04 / Intramural NIH HHS ZIA EY000403-14 / Intramural NIH HHS Z01 EY000403-06 / Intramural NIH HHS Z99 EY999999 / Intramural NIH HHS ZIA EY000426-09 / Intramural NIH HHS ZIA EY000426-07 / Intramural NIH HHS ZIA EY000403-09 / Intramural NIH HHS ZIA EY000426-11 / Intramural NIH HHS ZIA EY000426-13 / Intramural NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000357740200065
- Scopus ID
- 2-s2.0-84939806441
- Other Identifier
- 991021959046504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Ophthalmology