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Journal article
Age Matters: Key Contributors to Interferon Toxicity in Infants During Influenza Virus Infection
Viruses, v 17(7), 1002
17 Jul 2025
PMID: 40733618
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Abstract
Respiratory viral infections are a leading cause of early childhood hospitalizations in the United States. Neonatal immune responses are reliant on innate mechanisms during the first few months of life. Interferons (IFNs) are a key component of this response. These antiviral cytokines are produced early in infection and aid in viral control and clearance. Although generally considered protective in the setting of respiratory viral infections, the recent literature has suggested that IFNs may exacerbate disease. In the process of promoting an antiviral environment, IFNs impede cell proliferation, contribute to pulmonary barrier disruption, and generate reactive oxygen species. This is not tolerated in the rapidly developing neonatal lung. Therefore, IFNs contribute to pathogenesis in the influenza-infected neonate. This review focuses on the potential mechanisms that drive IFN-induced toxicity in neonates and prospective therapeutics to mitigate this toxicity.
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Details
- Title
- Age Matters: Key Contributors to Interferon Toxicity in Infants During Influenza Virus Infection
- Creators
- Alison J Carey (Corresponding Author) - Drexel University, PediatricsAbigail Onufer - Drexel University
- Publication Details
- Viruses, v 17(7), 1002
- Publisher
- MDPI
- Number of pages
- 18
- Grant note
- National Institutes of Health Institute of Allergy and Infectious Diseases
This work was supported by the National Institutes of Health Institute of Allergy and Infectious Diseases, R01AI149801 to A.J.C.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Pediatrics
- Web of Science ID
- WOS:001535862800001
- Scopus ID
- 2-s2.0-105011733759
- Other Identifier
- 991022064139904721
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- Web of Science research areas
- Virology