Logo image
Back
Age-Related Changes in Cardiac Norepinephrine Release: Role of Calcium Movement
Journal article   Peer reviewed

Age-Related Changes in Cardiac Norepinephrine Release: Role of Calcium Movement

David L. Snyder, Mark D. Johnson, Vince Aloyo, Bernard Eskin, Jay Roberts and James R Roberts
The journals of gerontology. Series A, Biological sciences and medical sciences, v 50A(6), pp B358-B367
Nov 1995
DOI: https://doi.org/10.1093/gerona/50A.6.B358
PMID: 7583792
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

The purpose of this study was to determine if the age-related decrease in norepinephrine (NE) release from cardiac adrenergic nerve terminals is due to a defect in Ca2+ movement into the nerve terminal or to an alteration inCa2+ activation of intracellular events leading to NE release. NE release was assessed in cardiac synaptosomes prepared from 6- and 24-month-old male F344 rats. K+-induced NE release was significantly greater in young vs old rats. Raising extracellular [Ca2+] increased NE release, but NE release always remained higher in the younger animals. Ionomycin, a Ca2+ ionophore, induced NE release from cardiac synaptosomes, and there was no age difference in the response. The age-related reduction in NE release induced by K+ and the capacity of ionomycin to induce similar NE release in young and old cardiac synaptosomes points to a reduction in Ca2+ movement during depolarization.

Metrics

9 Record Views
6 citations in Web of Science
7 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Web of Science research areas
Geriatrics & Gerontology
Gerontology
Logo image