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Journal article
Age-Related Increases in Posterior Hippocampal Granularity Are Associated with Remote Detailed Episodic Memory in Development
The Journal of neuroscience, v 41(8), pp 1738-1754
24 Feb 2021
PMID: 33443075
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Episodic memory is critical to human functioning. In adults, episodic memory involves a distributed neural circuit in which the hippocampus plays a central role. As episodic memory abilities continue to develop across childhood and into adolescence, studying episodic memory maturation can provide insight into the development and construction of these hippocampal networks, and ultimately dues to their function in adulthood. While past developmental studies have shown that the hippocampus helps to support memory in middle childhood and adolescence, the extent to which ongoing maturation within the hippocampus contributes to developmental change in episodic memory abilities remains unclear. In contrast, slower maturing regions, such as the PFC, have been suggested to be the neurobiological locus of memory improvements into adolescence. However, it is also possible that the methods used to detect hippocampal development during middle childhood and adolescence are not sensitive enough. Here, we examine how temporal covariance (or differentiation) in voxel representations within anterior and posterior hippocampus change with age to support the development of detailed recollection in male and female developing humans. We find age-related increases in the distinctiveness of temporal activation profiles in the posterior, but not anterior, hippocampus. Second, we show that this measure of granularity, when present during postencoding rest periods, correlates with the recall of detailed memories of preceding stimuli several weeks postencoding, suggesting that granularity may promote memory stabilization.
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Details
- Title
- Age-Related Increases in Posterior Hippocampal Granularity Are Associated with Remote Detailed Episodic Memory in Development
- Creators
- Bridget Callaghan - University of California, Los AngelesCamille Gasser - Columbia Univ, New York, NY 10027 USAJennifer A. Silvers - Univ Calif Los Angeles, Los Angeles, CA 90095 USAMichelle VanTieghem - Columbia Univ, New York, NY 10027 USATricia Choy - Univ Calif Riverside, Riverside, CA 92521 USAKaitlin O'Sullivan - Georgetown UniversityAlexa Tompary - University of PennsylvaniaLila Davachi - Columbia UniversityNim Tottenham - Columbia Univ, New York, NY 10027 USA
- Publication Details
- The Journal of neuroscience, v 41(8), pp 1738-1754
- Publisher
- Soc Neuroscience
- Number of pages
- 17
- Grant note
- New York State Psychiatric Institute 24739 / Brain Behavior Research Association K99MH113821-01 / National Institutes of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000621624200001
- Scopus ID
- 2-s2.0-85102322116
- Other Identifier
- 991021448165004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences