Journal article
Age and Sex Interact to Mediate the Effects of Intermittent, High-Dose Ethanol Exposure on Behavioral Flexibility
Frontiers in pharmacology, v 8, pp 450-450
07 Jul 2017
PMID: 28736526
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Human alcoholics have been shown to have impaired cognitive control over actions and increased reliance on habitual response strategies. While it is unclear in humans whether these differences predate ethanol exposure or result from chronic drinking, data from animal studies suggest that ethanol acts to promote the development of inflexible behaviors. Here, we investigated how intermittent exposure to high doses of ethanol impacts the ability to flexibly regulate behavior in a habit model. As adolescence, may represent a period of increased drug taking and developmental vulnerability that may impact adult behavior, we compared the effects of high-dose ethanol exposure during adolescence to exposure during adulthood in male and female rats. Our findings indicated that the effects of intermittent, high-dose ethanol exposure on habitual behavior is mediated by age and sex such that ethanol exposure during adolescence promoted the use of habitual response strategies in adult females, but not males, and that the opposite pattern emerged following intermittent, high-dose ethanol exposure in adult rats.
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Details
- Title
- Age and Sex Interact to Mediate the Effects of Intermittent, High-Dose Ethanol Exposure on Behavioral Flexibility
- Creators
- Jacqueline M. Barker - Medical University of South CarolinaKathleen G. Bryant - University of South CarolinaJennifer I. Osborne - Medical University of South CarolinaL. J. Chandler - Medical University of South Carolina
- Publication Details
- Frontiers in pharmacology, v 8, pp 450-450
- Publisher
- Frontiers Media Sa
- Number of pages
- 10
- Grant note
- AA023141; AA024499; AA010761 / NIH grants; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P50AA010761 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:000406163100001
- Scopus ID
- 2-s2.0-85025451339
- Other Identifier
- 991020099507904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pharmacology & Pharmacy