Journal article
Age-associated alterations of brain mitochondria energetics
Biochemical and biophysical research communications, v 643, pp 1-7
05 Feb 2023
PMID: 36584587
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The study aimed to explore the role of age-associated elevated cytosolic Ca2+ in changes of brain mitochondria energetic processes. Two groups of rats, young adults (4 months) and advanced old (24 months), were evaluated for potential alterations of mitochondrial parameters, the oxidative phosphorylation (OxPhos), membrane potential, calcium retention capacity, activity of glutamate/aspartate carrier (aralar), and ROS formation. We demonstrated that the brain mitochondria of older animals have a lower resistance to Ca2+ stress with resulting consequences. The suppressed complex I OxPhos and decreased membrane potential were accompanied by reduction of the Ca2+ threshold required for induction of mPTP. The Ca2+ binding sites of mitochondrial aralar mediated a lower activity of old brain mitochondria. The altered interaction between aralar and mPTP may underlie mitochondrial dysregulation leading to energetic depression during aging. At the advanced stages of aging, the declined metabolism is accompanied by the diminished oxidative background.
•Aged brain mitochondria intolerant to high cytosolic Ca2+content.•Complex I OxPhos, ΔΨm, Ca2+ retention capacity, ROS formation decline upon aging.•Activity of mitochondrial aralar decreases during aging.
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Details
- Title
- Age-associated alterations of brain mitochondria energetics
- Creators
- Timur Gainutdinov - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, GermanyZemfira Gizatullina - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, GermanyGrazyna Debska-Vielhaber - Otto-von-Guericke University MagdeburgStefan Vielhaber - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, GermanyRobert E. Feldmann - Heidelberg UniversityZulfiya Orynbayeva (Corresponding Author) - Drexel University, SurgeryFrank Norbert Gellerich - Department of Neurology, Otto von Guericke University, D-39120, Magdeburg, Germany
- Publication Details
- Biochemical and biophysical research communications, v 643, pp 1-7
- Publisher
- Elsevier Inc
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000914752400001
- Scopus ID
- 2-s2.0-85145289084
- Other Identifier
- 991021861173704721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics