Journal article
Age associated changes in mitogen induced proliferation and cytokine production by lymphocytes of the long-lived brown Norway rat
Mechanisms of ageing and development, v 71(3), pp 199-212
15 Oct 1993
PMID: 7510811
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The long-lived, inbred Brown Norway (BN) rat demonstrates an age associated decrease in lymphoproliferation in response to ConA; however, these declines only become apparent after the age of median survival, 31 months. Significant declines in IL-2 production after ConA stimulation also occur after median survival. In contrast, production of IFN after ConA stimulation increases with age in BN rats. This increase in IFN production begins about 12 months of age and plateaus at about median lifespan. The imbalance in IL-2 and IFN production may reflect a dysregulation that results in a decreased proliferative response of lymphocytes with increasing age.
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Details
- Title
- Age associated changes in mitogen induced proliferation and cytokine production by lymphocytes of the long-lived brown Norway rat
- Creators
- I M Goonewardene - Drexel UniversityD M Murasko - Drexel University
- Publication Details
- Mechanisms of ageing and development, v 71(3), pp 199-212
- Publisher
- Elsevier
- Grant note
- AG07719 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:A1993MJ24300004
- Scopus ID
- 2-s2.0-0027524923
- Other Identifier
- 991020950477504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology