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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Age-associated loss of selectivity in human olfactory sensory neurons
Neurobiology of aging, v 33(9), pp 1913-1919
Sep 2012
PMID: 22074806
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We report a cross-sectional study of olfactory impairment with age based on both odorant-stimulated responses of human olfactory sensory neurons (OSNs) and tests of olfactory threshold sensitivity. A total of 621 OSNs from 440 subjects in 2 age groups of younger (≤ 45 years) and older (≥ 60 years) subjects were investigated using fluorescence intensity ratio fura-2 imaging. OSNs were tested for responses to 2 odorant mixtures, as well as to subsets of and individual odors in those mixtures. Whereas cells from younger donors were highly selective in the odorants to which they responded, cells from older donors were more likely to respond to multiple odor stimuli, despite a loss in these subjects' absolute olfactory sensitivity, suggesting a loss of specificity. This degradation in peripheral cellular specificity may impact odor discrimination and olfactory adaptation in the elderly. It is also possible that chronic adaptation as a result of reduced specificity contributes to observed declines in absolute sensitivity.
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Details
- Title
- Age-associated loss of selectivity in human olfactory sensory neurons
- Creators
- Nancy E. Rawson - Monell Chemical Senses CenterGeorge Gomez - University of ScrantonBeverly J. Cowart - Monell Chemical Senses CenterAndres Kriete - Drexel UniversityEdmund Pribitkin - Monell Chemical Senses CenterDiego Restrepo - University of Colorado Anschutz Medical Campus
- Publication Details
- Neurobiology of aging, v 33(9), pp 1913-1919
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000306994600005
- Scopus ID
- 2-s2.0-84863434140
- Other Identifier
- 991019168215504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology
- Neurosciences