Journal article
Age-related alterations in GABA A receptor subunits in the nonhuman primate hippocampus
Brain research, v 1073, pp 120-130
2006
PMID: 16430870
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pharmacological studies have documented that altered drug responses, particularly to benzodiazepines, are common in elderly populations. While numerous factors may contribute to changes in drug response, age-related alterations in the molecular composition of GABA
A receptors may be a key factor in regulating these responses. We employed quantitative densitometry to examine the cytological features and density of highly prevalent hippocampal GABA
A receptor subunits (α1 and β2/3) in young and aged rhesus monkeys. α1 and β2/3 subunit immunostaining was differentially distributed throughout the hippocampus. In addition, β2/3 immunolabeling in aged monkeys was characterized by marked intersubject variability in labeling intensity, with dramatic reductions present in 3 of 5 samples. α1 immunolabeling in aged monkeys was significantly reduced in the CA2 and CA3 subregions, and in hilus/polymorphic layer of the dentate gyrus. Collectively, our findings demonstrate that not only are GABA
A receptor subunits differentially distributed throughout the hippocampus, but they are also differentially altered with increased age—changes that may have an important impact on the binding properties of GABA
A receptor pharmacological agents.
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Details
- Title
- Age-related alterations in GABA A receptor subunits in the nonhuman primate hippocampus
- Creators
- Robert A. Rissman - Drexel UniversityRomy Nocera - Lankenau Institute for Medical ResearchLaura M. Fuller - Lankenau Institute for Medical ResearchJeffrey H. Kordower - Department of Neurological Sciences, Rush Presbyterian Medical Center, Chicago, IL 60612, USADavid M. Armstrong - Lankenau Institute for Medical Research
- Publication Details
- Brain research, v 1073, pp 120-130
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:000236662400014
- Scopus ID
- 2-s2.0-33644953455
- Other Identifier
- 991019167891604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences