Journal article
Age-related changes in Type 1 and Type 2 cytokine production in humans
Biogerontology (Dordrecht), v 3(5)
2002
PMID: 12237564
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Although aging is accompanied by several changes in immune function, altered T cell function represents the most consistent and dramatic change. Since cytokines modulate the immune response, it has been postulated that these age-associated changes in T cell function may be due to alterations in cytokine production. Data from murine studies generally support an age-related shift from a Th1-like (IL-2, IFN-gamma) to a Th2-like (IL-4, IL-6, IL-10) cytokine response; however, whether or not such an age-related shift to a Type 2 cytokine response occurs in humans is not certain. This review of over 60 studies in humans, in which Type 1 and Type 2 cytokines were evaluated either alone or together, suggests that age-associated changes in cytokine production are inconsistent. Further, these age-associated changes in cytokine production do not always induce a shift to a Type 2 cytokine response. Importantly, these studies highlight that the stimulus used to induce cytokines influences both the level and pattern of immune response. Additional comprehensive evaluations in human studies are both critical and necessary to clearly identify the impact of altered cytokine production on age-related changes in immune function.
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Details
- Title
- Age-related changes in Type 1 and Type 2 cytokine production in humans
- Creators
- Elizabeth M Gardner - Department of Microbiology and Immunology, MCP Hahnemann University School of Medicine, Philadelphia, PA 19129, USA. eg25@drexel.eduDonna M Murasko
- Publication Details
- Biogerontology (Dordrecht), v 3(5)
- Publisher
- Netherlands
- Grant note
- AG 03934 / NIA NIH HHS AG 14913 / NIA NIH HHS AG 18641 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000177874500003
- Scopus ID
- 2-s2.0-0036402101
- Other Identifier
- 991014878587604721
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- Web of Science research areas
- Geriatrics & Gerontology