Journal article
Age-related changes in the immune response to influenza vaccination in a racially diverse, healthy elderly population
Vaccine, v 24(10), pp 1609-1614
2006
PMID: 16260072
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Proliferation to phytohemagglutinin (PHA) and cell-mediated responses to influenza vaccine (FLU) were assessed in healthy elderly Caucasians, African Americans, Latinos and young Caucasians before and after immunization. Both PHA- and FLU-induced proliferation were reduced in elderly subgroups. FLU-induced proliferation increased post-vaccination in all elderly, except African Americans, but responses were lower than young. IL-2 and IFN-γ levels did not change after vaccination of elderly, regardless of race. The altered response to FLU in elderly African Americans, compared to elderly Caucasians and Latinos, indicates that racial background is important when drawing conclusions about immune responses to FLU in mixed elderly populations.
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Details
- Title
- Age-related changes in the immune response to influenza vaccination in a racially diverse, healthy elderly population
- Creators
- Elizabeth M Gardner - Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USAElizabeth W Gonzalez - School of Nursing and Health Professions, Drexel Universtity, Philadelphia, PA 19129, USAShoko Nogusa - Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USADonna M Murasko - Department of Bioscience and Biotechnology, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
- Publication Details
- Vaccine, v 24(10), pp 1609-1614
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000236259500016
- Scopus ID
- 2-s2.0-32544460972
- Other Identifier
- 991014877818104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental