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Aggravation of seizures and/or EEG features in children treated with oxcarbazepine monotherapy
Journal article   Open access   Peer reviewed

Aggravation of seizures and/or EEG features in children treated with oxcarbazepine monotherapy

Martina Vendrame, Divya S Khurana, Marcos Cruz, Joseph Melvin, Ignacio Valencia, Agustin Legido and Sanjeev V Kothare
Epilepsia (Copenhagen), v 48(11), pp 2116-2120
Nov 2007
DOI: https://doi.org/10.1111/j.1528-1167.2007.01210.x
PMID: 17645535
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1111/j.1528-1167.2007.01210.xView
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Acute Disease Adolescent Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Carbamazepine - adverse effects Carbamazepine - analogs & derivatives Carbamazepine - therapeutic use Cerebral Cortex - physiopathology Child Child, Preschool Electroencephalography - drug effects Electroencephalography - statistics & numerical data Epilepsy - chemically induced Epilepsy - diagnosis Epilepsy - drug therapy Female Follow-Up Studies Humans Male Neurologic Examination Retrospective Studies Treatment Outcome
Exacerbation of epilepsy may occur following initiation of therapy with antiepileptic drugs (AEDs). The aim of this study is to analyze the clinical and EEG characteristics of a group of pediatric patients with worsening of seizures and/or EEG deterioration while on oxcarbazepine (OXC). A retrospective analysis of a clinical database was performed to identify patients with epilepsy treated with OXC over the past 3 years. History, neurological examination, and EEG findings were reviewed to identify any who had developed exacerbation of seizures or new abnormalities on EEG. Of 290 patients on OXC, we identified 12 patients with new onset seizures, all with initial normal neurological exam and normal EEG, who developed either worsening of preexisting seizures, new seizure types, and/or EEG deterioration following introduction of OXC monotherapy. EEG changes were primarily characterized by new onset of generalized epileptiform activity not reported on the initial baseline EEG. Following substitution of OXC with a broad spectrum AED, significant improvement of seizure control and improvement in the EEG was observed. These findings suggest that OXC can aggravate seizures and/or worsen EEG features in children. Following initiation of therapy with OXC, monitoring of patients with follow-up EEGs may be important, especially in patients who do not show adequate response to therapy.

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Web of Science research areas
Clinical Neurology
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