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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Aggrecan Nanoscale Solid—Fluid Interactions Are a Primary Determinant of Cartilage Dynamic Mechanical Properties
ACS nano, v 9(3), pp 2614-2625
13 Mar 2015
PMID: 25758717
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Poroelastic interactions between interstitial fluid and the extracellular matrix of connective tissues are critical to biological and pathophysiological functions involving solute transport, energy dissipation, self-stiffening and lubrication. However, the molecular origins of poroelasticity at the nanoscale are largely unknown. Here, the broad-spectrum dynamic nanomechanical behavior of cartilage aggrecan monolayer is revealed for the first time, including the equilibrium and instantaneous moduli and the peak in the phase angle of the complex modulus. By performing a length scale study and comparing the experimental results to theoretical predictions, we confirm that the mechanism underlying the observed dynamic nanomechanics is due to solid–fluid interactions (poroelasticity) at the molecular scale. Utilizing finite element modeling, the molecular-scale hydraulic permeability of the aggrecan assembly was quantified (
k
aggrecan
= (4.8 ± 2.8) × 10
−15
m
4
/N • s) and found to be similar to the nanoscale hydraulic permeability of intact normal cartilage tissue but much lower than that of early diseased tissue. The mechanisms underlying aggrecan poroelasticity were further investigated by altering electrostatic interactions between the molecule’s constituent glycosaminoglycan chains: electrostatic interactions dominated steric interactions in governing molecular behavior. While the hydraulic permeability of aggrecan layers does not change across species and age, aggrecan from adult human cartilage is stiffer than the aggrecan from newborn human tissue.
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Details
- Title
- Aggrecan Nanoscale Solid—Fluid Interactions Are a Primary Determinant of Cartilage Dynamic Mechanical Properties
- Creators
- Hadi Tavakoli Nia - Massachusetts Institute of TechnologyLin Han - Drexel UniversityIman Soltani Bozchalooi - Massachusetts Institute of TechnologyPeter Roughley - Shriners Hospitals for Children - CanadaKamal Youcef-Toumi - Massachusetts Institute of TechnologyAlan J. Grodzinsky - Massachusetts Institute of TechnologyChristine Ortiz - Massachusetts Institute of Technology
- Publication Details
- ACS nano, v 9(3), pp 2614-2625
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000351791800037
- Scopus ID
- 2-s2.0-84925637002
- Other Identifier
- 991019168546004721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology