Journal article
Aggregation and disaggregation of senile plaques in Alzheimer disease
Proceedings of the National Academy of Sciences - PNAS, v 94(14), pp 7612-7616
08 Jul 1997
PMID: 9207140
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We quantitatively analyzed, using laser scanning confocal microscopy, the three-dimensional structure of individual senile plaques in Alzheimer disease. We carried out the quantitative analysis using statistical methods to gain insights about the processes that govern
A
β peptide deposition. Our results show that plaques are complex porous structures with characteristic pore sizes. We interpret plaque morphology in the context of a new dynamical model based on competing aggregation and disaggregation processes in kinetic steady-state equilibrium with an additional diffusion process allowing
A
β deposits to diffuse over the surface of plaques.
Metrics
Details
- Title
- Aggregation and disaggregation of senile plaques in Alzheimer disease
- Creators
- L Cruz - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215B Urbanc - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215S. V Buldyrev - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215R Christie - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215T Gómez-Isla - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215S Havlin - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215M McNamara - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215H. E Stanley - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215B. T Hyman - Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 94(14), pp 7612-7616
- Publisher
- The National Academy of Sciences of the USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:A1997XJ87600088
- Scopus ID
- 2-s2.0-0030739442
- Other Identifier
- 991014878420904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology