Journal article
Aggressive B-cell Lymphoma Masquerading as Benign Epstein-Barr Virus (EBV)-Related Splenomegaly: An Analysis of Diagnostic Anchoring Bias
Curēus (Palo Alto, CA), v 18(6), e110931
Jun 2026
PMID: 42465140
Abstract
We report a case involving a 52-year-old male who was initially diagnosed with Epstein-Barr virus (EBV)-related splenomegaly and subsequently identified as having an aggressive B-cell lymphoproliferative disorder. Despite multiple initial diagnostic tests yielding negative results, persistent clinical suspicion due to the worsening patient's condition warranted further investigation, ultimately establishing the correct diagnosis. This case underscores the diagnostic challenges in distinguishing benign viral-associated splenomegaly from underlying malignant lymphoproliferative disorders and highlights the importance of maintaining clinical vigilance when initial diagnostic findings are discordant with the clinical presentation.
Metrics
1 Record Views
Details
- Title
- Aggressive B-cell Lymphoma Masquerading as Benign Epstein-Barr Virus (EBV)-Related Splenomegaly: An Analysis of Diagnostic Anchoring Bias
- Creators
- Amrut Savadkar - St. Joseph Medical CenterIpsita Chauhan - Flushing Hospital Medical CenterMansi Sharma - Wayne Community CollegeSuhasini Rallabandi - Banner HealthPratibha Patil - Community Medical CentersVaishali Benaka HebbarRahul Kashyap - Mayo Clinic
- Publication Details
- Curēus (Palo Alto, CA), v 18(6), e110931
- Publisher
- Cureus
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Other Identifier
- 991022201734504721