Journal article
Air Pollution Exposure and Abnormal Glucose Tolerance during Pregnancy: The Project Viva Cohort
Environmental health perspectives, v 122(4), pp 378-383
01 Apr 2014
PMID: 24508979
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BACKGROUND: Exposure to fine particulate matter (PM with diameter <= 2.5 mu m; PM2.5) has been linked to type 2 diabetes mellitus, but associations with hyperglycemia in pregnancy have not been well studied.
METHODS: We studied Boston, Massachusetts-area pregnant women without known diabetes. We identified impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM) during pregnancy from clinical glucose tolerance tests at median 28.1 weeks gestation. We used residential addresses to estimate second-trimester PM2.5 and black carbon exposure via a central monitoring site and spatiotemporal models. We estimated residential traffic density and roadway proximity as surrogates for exposure to traffic-related air pollution. We performed multinomial logistic regression analyses adjusted for sociodemographic covariates, and used multiple imputation to account for missing data.
RESULTS: Of 2,093 women, 65 (3%) had IGT and 118 (6%) had GDM. Second-trimester spatiotemporal exposures ranged from 8.5 to 15.9 mu g/m(3) for PM2.5 and from 0.1 to 1.7 mu g/m(3) for black carbon. Traffic density was 0-30,860 vehicles/day x length of road (kilometers) within 100 m; 281 (13%) women lived <= 200 m from a major road. The prevalence of IGT was elevated in the highest (vs. lowest) quartile of exposure to spatiotemporal PM2.5 [odds ratio (OR) = 2.63; 95% CI: 1.15, 6.01] and traffic density (OR = 2.66; 95% CI: 1.24, 5.71). IGT also was positively associated with other exposure measures, although associations were not statistically significant. No pollutant exposures were positively associated with GDM.
CONCLUSIONS: Greater exposure to PM2.5 and other traffic-related pollutants during pregnancy was associated with IGT but not GDM. Air pollution may contribute to abnormal glycemia in pregnancy.
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Details
- Title
- Air Pollution Exposure and Abnormal Glucose Tolerance during Pregnancy: The Project Viva Cohort
- Creators
- Abby F. Fleisch - Boston Children's HospitalDiane R. Gold - Brigham and Women's HospitalSheryl L. Rifas-Shiman - Harvard UniversityPetros Koutrakis - Harvard UniversityJoel D. Schwartz - Harvard UniversityItai Kloog - Ben-Gurion University of the NegevSteven Melly - Harvard UniversityBrent A. Coull - Cancer Research And BiostatisticsAntonella Zanobetti - Harvard UniversityMatthew W. Gillman - Harvard Pilgrim Health CareEmily Oken - Harvard Pilgrim Health Care
- Publication Details
- Environmental health perspectives, v 122(4), pp 378-383
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 6
- Grant note
- T32HS000063 / AGENCY FOR HEALTHCARE RESEARCH AND QUALITY; United States Department of Health & Human Services; Agency for Healthcare Research & Quality R01HD034568 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) RD83479801 / U.S. Environmental Protection Agency; United States Environmental Protection Agency P30ES000002 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) K24 HD069408; R01HD 034568; P30 DK092924; P03ES000002; P01 ES009825; K12 DK094721-02 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Harvard School of Public Health Harvard Pilgrim Health Care Institute P30DK092924 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) T32 HS000063 / Agency for Healthcare Research and Quality; United States Department of Health & Human Services; Agency for Healthcare Research & Quality
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000334069100021
- Scopus ID
- 2-s2.0-84897445524
- Other Identifier
- 991021875342604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology