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Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis
Journal article   Open access   Peer reviewed

Air pollution exposure is associated with MRSA acquisition in young U.S. children with cystic fibrosis

Kevin J Psoter, Anneclaire J De Roos, Jon Wakefield, Jonathan D Mayer and Margaret Rosenfeld
BMC pulmonary medicine, v 17(1), pp 106-106
27 Jul 2017
DOI: https://doi.org/10.1186/s12890-017-0449-8
PMID: 28750627
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1186/s12890-017-0449-8View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

Achromobacter denitrificans Air Pollution Carrier State - epidemiology Carrier State - microbiology Child Child, Preschool Cohort Studies Cystic Fibrosis - epidemiology Cystic Fibrosis - microbiology Environmental Exposure - statistics & numerical data Female Gram-Negative Bacterial Infections - epidemiology Gram-Negative Bacterial Infections - microbiology Humans Infant Male Methicillin-Resistant Staphylococcus aureus Multivariate Analysis Particulate Matter Regression Analysis Respiratory Tract Infections - epidemiology Respiratory Tract Infections - microbiology Retrospective Studies Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Stenotrophomonas maltophilia United States
The role of air pollution in increasing susceptibility to respiratory tract infections in the cystic fibrosis (CF) population has not been well described. We recently demonstrated that chronic PM exposure is associated with an increased risk of initial Pseudomonas aeruginosa acquisition in young children with CF. The purpose of this study was to determine whether PM exposure is a risk factor for acquisition of other respiratory pathogens in young children with CF. We conducted a retrospective study of initial acquisition of methicillin susceptible and methicillin resistant Staphylococcus aureus (MSSA and MRSA), Stenotrophomonas maltophilia and Achromobacter xylosoxidans in U.S. children <6 years of age with CF using the CF Foundation Patient Registry, 2003-2009. Multivariable Weibull regression with interval-censored outcomes was used to evaluate the association of PM concentration in the year prior to birth and risk of acquisition of each organism. During follow-up 63%, 17%, 24%, and 5% of children acquired MSSA, MRSA, S. maltophilia, and A. xylosoxidans, respectively. A 10 μg/m increase in PM exposure was associated with a 68% increased risk of MRSA acquisition (Hazard Ratio: 1.68; 95% Confidence Interval: 1.24, 2.27). PM was not associated with acquisition of other respiratory pathogens. Fine particulate matter is an independent risk factor for initial MRSA acquisition in young children with CF. These results support the increasing evidence that air pollution contributes to pulmonary morbidities in the CF community.

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38 citations in Web of Science
36 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Respiratory System
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