Journal article
Air pollution, inflammation and preterm birth: a potential mechanistic link
Medical hypotheses, v 82(2)
Feb 2014
PMID: 24382337
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Preterm birth is a public health issue of global significance, which may result in mortality during the perinatal period or may lead to major health and financial consequences due to lifelong impacts. Even though several risk factors for preterm birth have been identified, prevention efforts have failed to halt the increasing rates of preterm birth. Epidemiological studies have identified air pollution as an emerging potential risk factor for preterm birth. However, many studies were limited by study design and inadequate exposure assessment. Due to the ubiquitous nature of ambient air pollution and the potential public health significance of any role in causing preterm birth, a novel focus investigating possible causal mechanisms influenced by air pollution is therefore a global health priority. We hypothesize that air pollution may act together with other biological factors to induce systemic inflammation and influence the duration of pregnancy. Evaluation and testing of this hypothesis is currently being conducted in a prospective cohort study in Mexico City and will provide an understanding of the pathways that mediate the effects of air pollution on preterm birth. The important public health implication is that crucial steps in this mechanistic pathway can potentially be acted on early in pregnancy to reduce the risk of preterm birth.
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Details
- Title
- Air pollution, inflammation and preterm birth: a potential mechanistic link
- Creators
- Felipe Vadillo-Ortega - Unidad de Vinculación de la Facultad de Medicina, U.N.A.M., Instituto Nacional de Medicina Genómica, Mexico City, Mexico. Electronic address: felipe.vadillo@gmail.comAlvaro Osornio-Vargas - Department of Paediatrics, University of Alberta, Edmonton, AB, CanadaMiatta A Buxton - University of Michigan School of Public Health, Ann Arbor, MI, USABrisa N Sánchez - University of Michigan School of Public Health, Ann Arbor, MI, USALeonora Rojas-Bracho - Instituto Nacional de Ecología, Mexico City, MexicoMartin Viveros-Alcaráz - Hospital Materno Infantil Inguarán, Secretaria de Salud del Gobierno del D.F., Mexico City, MexicoMarisol Castillo-Castrejón - Unidad de Vinculación de la Facultad de Medicina, U.N.A.M., Instituto Nacional de Medicina Genómica, Mexico City, MexicoJorge Beltrán-Montoya - Instituto Nacional de Perinatología Isidro Espìnosa de los Reyes, Mexico City, MexicoDaniel G Brown - University of Michigan School of Natural Resources & Environment, Ann Arbor, MI, USAMarie S O'Neill - University of Michigan School of Public Health, Ann Arbor, MI, USA
- Publication Details
- Medical hypotheses, v 82(2)
- Publisher
- Elsevier; United States
- Grant note
- R01 ES016932 / NIEHS NIH HHS P30 ES017885 / NIEHS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000331028700021
- Scopus ID
- 2-s2.0-84892366240
- Other Identifier
- 991014877701004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental