Journal article
Air pollution, inflammation and preterm birth in Mexico City: Study design and methods
The Science of the total environment, v 448, pp 79-83
15 Mar 2013
PMID: 23177781
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Preterm birth is one of the leading causes of perinatal mortality and is associated with long-term adverse health consequences for surviving infants. Preterm birth rates are rising worldwide, and no effective means for prevention currently exists. Air pollution exposure may be a significant cause of prematurity, but many published studies lack the individual, clinical data needed to elucidate possible biological mechanisms mediating these epidemiological associations. This paper presents the design of a prospective study now underway to evaluate those mechanisms in a cohort of pregnant women residing in Mexico City. We address how air quality may act together with other factors to induce systemic inflammation and influence the duration of pregnancy. Data collection includes: biomarkers relevant to inflammation in cervico-vaginal exudate and peripheral blood, along with full clinical information, pro-inflammatory cytokine gene polymorphisms and air pollution data to evaluate spatial and temporal variability in air pollution exposure. Samples are collected on a monthly basis and participants are followed for the duration of pregnancy. The data will be used to evaluate whether ambient air pollution is associated with preterm birth, controlling for other risk factors. We will evaluate which time windows during pregnancy are most influential in the air pollution and preterm birth association. In addition, the epidemiological study will be complemented with a parallel toxicology invitro study, in which monocytic cells will be exposed to air particle samples to evaluate the expression of biomarkers of inflammation.
► Air pollution exposure may be a risk factor for preterm births. ► Inflammatory mechanisms are hypothesized to play an important role. ► We present the design and methods for a new epidemiologic study in Mexico City. ► Innovative aspects include repeated measures and a parallel toxicology study. ► The study should provide new knowledge on mechanisms and guide prevention.
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Details
- Title
- Air pollution, inflammation and preterm birth in Mexico City: Study design and methods
- Creators
- Marie S O´Neill - University of Michigan School of Public Health, Ann Arbor, MI, USAAlvaro Osornio-Vargas - Instituto Nacional de Cancerología, Mexico City, Mexico1Miatta A Buxton - University of Michigan School of Public Health, Ann Arbor, MI, USABrisa N Sánchez - University of Michigan School of Public Health, Ann Arbor, MI, USALeonora Rojas-Bracho - Instituto Nacional de Ecología, Mexico City, MexicoMarisol Castillo-Castrejon - Universidad Nacional Autonoma de Mexico, Unidad Mixta Facultad de Medicina, UNAM/INMEGEN, Instituto Nacional de Medicina Genómica, Facultad de Medicina, Av. Universidad 3000, Delegacion Coyoacan, D.F. 04510, MexicoIrina B Mordhukovich - University of North Carolina Gillings School of Public Health, Chapel Hill, NC, USADaniel G Brown - University of Michigan School of Natural Resources & Environment, Ann Arbor, MI, USAFelipe Vadillo-Ortega - Universidad Nacional Autonoma de Mexico, Unidad Mixta Facultad de Medicina, UNAM/INMEGEN, Instituto Nacional de Medicina Genómica, Facultad de Medicina, Av. Universidad 3000, Delegacion Coyoacan, D.F. 04510, Mexico
- Publication Details
- The Science of the total environment, v 448, pp 79-83
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000318132700010
- Scopus ID
- 2-s2.0-84875263447
- Other Identifier
- 991014877720004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences