Journal article
Airborne particulate matter exposure and urinary albumin excretion: the Multi-Ethnic Study of Atherosclerosis
Occupational and environmental medicine (London, England), v 65(8), pp 534-540
01 Aug 2008
PMID: 18032533
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives: Understanding mechanistic pathways linking airborne particle exposure to cardiovascular health is important for causal inference and setting environmental standards. We evaluated whether urinary albumin excretion, a subclinical marker of microvascular function which predicts cardiovascular events, was associated with ambient particle exposure.
Methods: Urinary albumin and creatinine were measured among members of the Multi-Ethnic Study of Atherosclerosis at three visits during 2000-2004. Exposure to PM2.5 and PM10 (mu g/m(3)) was estimated from ambient monitors for 1 month, 2 months and two decades before visit one. We regressed recent and chronic ( 20 year) particulate matter ( PM) exposure on urinary albumin/creatinine ratio (UACR, mg/g) and microalbuminuria at first examination, controlling for age, race/ethnicity, sex, smoking, second-hand smoke exposure, body mass index and dietary protein (n = 3901). We also evaluated UACR changes and development of microalbuminuria between the first, and second and third visits which took place at 1.5- to 2-year intervals in relation to chronic PM exposure prior to baseline using mixed models.
Results: Chronic and recent particle exposures were not associated with current UACR or microalbuminuria (per 10 mu g/m(3) increment of chronic PM10 exposure, mean difference in log UACR = 20.02 (95% CI -0.07 to 0.03) and relative probability of having microalbuminuria = 0.92 ( 95% CI 0.77 to 1.08)) We found only weak evidence that albuminuria was accelerated among those chronically exposed to particles: each 10 mg/m(3) increment in chronic PM10 exposure was associated with a 1.14 relative probability of developing microalbuminuria over 3 4 years, although 95% confidence intervals included the null ( 95% CI 0.96 to 1.36).
Conclusions: UACR is not a strong mechanistic marker for the possible influence of air pollution on cardiovascular health in this sample.
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Details
- Title
- Airborne particulate matter exposure and urinary albumin excretion: the Multi-Ethnic Study of Atherosclerosis
- Creators
- M. S. O'Neill (Corresponding Author) - Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USAA. V. Diez-Roux - University of MichiganA. H. Auchincloss - University of MichiganT. G. Franklin - University of MichiganD. R. Jacobs - University of MinnesotaB. C. Astor - University of Wisconsin–MadisonJ. T. Dvonch - University of MichiganJ. Kaufman - University of Washington
- Publication Details
- Occupational and environmental medicine (London, England), v 65(8), pp 534-540
- Publisher
- BMJ Publishing Group
- Number of pages
- 7
- Grant note
- K24 ES013195-02; K24 ES013195-01A1; K24 ES013195 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) K24ES013195 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01-HC-95163; N01HC95165; N01-HC-95164; N01-HC-95162; N01HC95159; N01-HC-95161; N01-HC-95160; N01-HC-95169; N01HC95169; N01-HC-95159; N01-HC-95165 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R43HL095169 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) N01HC095161 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000257885200004
- Scopus ID
- 2-s2.0-48949087364
- Other Identifier
- 991014878278004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health