Journal article
Airway Microbiome and Development of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review
The Journal of pediatrics, v 204, pp 126-133
Jan 2019
PMID: 30297287
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To summarize evidence regarding microbial dysbiosis of the airway associated with bronchopulmonary dysplasia (BPD) and to explore heterogeneity among studies.
We included studies that evaluated the airway microbiome in preterm infants who developed BPD using culture-independent molecular techniques and reported alpha- and beta-diversity metrics and microbial profiles.
The 6 included studies had substantial clinical and methodological heterogeneity. Most studies reported the presence of an airway microbiome early after birth and an evolution in the first weeks of life with increasing bacterial loads. The early airway microbiome was dominated by Staphylococcus and Ureaplasma spp. Two studies reported differences in alpha- and beta- diversity indices in preterm infants with BPD compared with those who did not develop BPD. Increased microbial community turnover, changes in the relative abundance of Proteobacteria and Firmicutes, and decreased Lactobacilli were reported with BPD progression. Most included infants were born by cesarean delivery, and a majority were exposed to postnatal antibiotics. No data regarding feeding human milk or correlations with the development of gut microbiota (gut-lung axis) were available.
Microbial dysbiosis may be associated with BPD progression and severity, and further study of microbiome optimization in preterm infants at risk for BPD is warranted.
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Details
- Title
- Airway Microbiome and Development of Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review
- Creators
- Mohan Pammi - Section of Neonatology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TXCharitharth Vivek Lal - University of Alabama at BirminghamBrandie D. Wagner - University of Colorado DenverPeter M. Mourani - University of Colorado DenverPablo Lohmann - Section of Neonatology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TXRuth Ann Luna - Texas Children's HospitalAmy Sisson - Texas Medical CenterBinoy Shivanna - Section of Neonatology, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TXEmily B. Hollister - Texas Children's HospitalSteven H. Abman - University of Colorado BoulderJames Versalovic - Texas Children's HospitalGary J. Connett - Department of Pediatrics, Southampton University Hospitals NHS Trust, Southampton, United KingdomVineet Bhandari - Drexel UniversityNamasivayam Ambalavanan - University of Alabama at Birmingham
- Publication Details
- The Journal of pediatrics, v 204, pp 126-133
- Publisher
- Elsevier
- Grant note
- Gerber Foundation (http://dx.doi.org/10.13039/100001130) 17SDG32720009 / American Heart Association (http://dx.doi.org/10.13039/100000968) NHLBI R01 HL129907; NHLBI R01 HL085703; P30DK056338 / National Institutes of Health (http://dx.doi.org/10.13039/100000002)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000453785200024
- Scopus ID
- 2-s2.0-85054398941
- Other Identifier
- 991019167338904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics