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Journal article
Albumin as a prognostic marker for ulcerative colitis
World journal of gastroenterology : WJG, v 23(45), pp 8008-8016
07 Dec 2017
PMID: 29259376
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
AIM
To evaluate the role of albumin at the time of ulcerative colitis (UC) diagnosis in predicting the clinical course of disease.
METHODS
Nationwide cohort of patients with newly diagnosed UC in the Veterans Affairs health care system was identified and divided into two categories: hypoalbuminemia (i.e., = 3.5 gm/dl) or normal albumin levels (i.e., > 3.5 gm/dl) at the time of UC diagnosis. The exposure of interest was presence of hypoalbuminemia defined as albumin level = 3.5 g/dl at the time of UC diagnosis. Patients were then followed over time to identify the use of = 2 courses of corticosteroids (CS), thiopurines, anti-TNF medications and requirement of colectomy for UC management.
RESULTS
The eligible study cohort included 802 patients, but 92 (11.4%) patients did not have their albumin levels checked at the time of UC diagnosis, and they were excluded. A total of 710 patients, who had albumin levels checked at time of UC diagnosis, were included in our study. Amongst them, 536 patients had a normal albumin level and 174 patients had hypoalbuminemia. Patients with hypoalbuminemia at diagnosis had a higher likelihood of = 2 courses of CS use (adjusted HR = 1.7, 95% CI: 1.3-2.3), higher likelihood of thiopurine or anti-TNF use (adjusted HR = 1.72, 95% CI: 1.23-2.40) than patients with normal albumin level at diagnosis. There was a trend of higher likelihood of colectomy in hypoalbuminemic patients, but it was not statistically significant (Adjusted HR = 1.7, 95% CI: 0.90-3.25).
CONCLUSION
Hypoalbuminemia at disease diagnosis can serve as a prognostic marker to predict the clinical course of UC at the time of diagnosis.
Metrics
Details
- Title
- Albumin as a prognostic marker for ulcerative colitis
- Creators
- Nabeel Khan - University of PennsylvaniaDhruvan Patel - Drexel UniversityYash Shah - Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, James J. Peters VA Medical Center, Bronx, NY 10468, United States.Chinmay Trivedi - Philadelphia VA Medical CenterYu-Xiao Yang - University of Pennsylvania
- Publication Details
- World journal of gastroenterology : WJG, v 23(45), pp 8008-8016
- Publisher
- Baishideng Publishing Group Inc
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Gastroenterology and Hepatology
- Web of Science ID
- WOS:000416927800007
- Scopus ID
- 2-s2.0-85038570405
- Other Identifier
- 991019168858604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Gastroenterology & Hepatology