Journal article
Alcohol Consumption and Cardiac Biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study
Clinical chemistry (Baltimore, Md.), v 62(9), pp 1202-1210
01 Sep 2016
PMID: 27440513
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of alcohol in the development of subclinical cardiovascular disease is unclear. We examined the association between alcohol consumption and markers of subclinical cardiac damage and wall stress.
We studied the cross-sectional and prospective associations of alcohol consumption with high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP) measured at 2 time points, 6 years apart (baseline, 1990-1992; follow-up, 1996-1998), in over 11000 participants of the Atherosclerosis Risk in Communities (ARIC) Study with no history of cardiovascular disease. Alcohol consumption was categorized as follows: never, former, current: ≤1, 2-7, 8-14, and ≥15 drinks/week.
Compared to never drinkers, persons who consumed 2-7 drinks per week were less likely to have increased hs-cTnT (≥14 ng/L) at baseline (odds ratio = 0.67, 95% CI, 0.46-0.96), and had a lower risk of incident increases in hs-cTnT at follow-up (relative risk = 0.70, 95% CI, 0.49-1.00). Conversely, there was a positive association between alcohol intake and NT-proBNP concentrations at baseline. Consumption of ≥15 drinks/week was positively associated with incident increases in NT-proBNP (≥300 pg/mL) at the 6-year follow-up visit (relative risk = 2.38, 95% CI, 1.43-3.96).
In this community-based study of middle-aged adults without a history of cardiovascular disease, moderate drinking was associated with lower concentrations of hs-cTnT, a marker of chronic subclinical myocardial damage, and positively associated with NT-proBNP, a biomarker of cardiac wall stress. Our results suggest that the cardiac effects of alcohol are complex. Cardiac biomarkers may help improve our understanding of the full cardiovascular effects of alcohol consumption.
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Details
- Title
- Alcohol Consumption and Cardiac Biomarkers: The Atherosclerosis Risk in Communities (ARIC) Study
- Creators
- Mariana Lazo - Johns Hopkins MedicineYuan Chen - Johns Hopkins UniversityJohn W McEvoy - Johns Hopkins UniversityChiadi Ndumele - Johns Hopkins UniversitySuma Konety - University of MinnesotaChristie M Ballantyne - Baylor College of MedicineA Richey Sharrett - Johns Hopkins UniversityElizabeth Selvin - Johns Hopkins University
- Publication Details
- Clinical chemistry (Baltimore, Md.), v 62(9), pp 1202-1210
- Grant note
- HHSN268201100010C / NHLBI NIH HHS HHSN268201100005C / NHLBI NIH HHS HHSN268201100007C / NHLBI NIH HHS HHSN268201100008C / NHLBI NIH HHS HHSN268201100012C / NHLBI NIH HHS HHSN268201100008I / NHLBI NIH HHS HHSN268201100005G / NHLBI NIH HHS HHSN268201100005I / NHLBI NIH HHS HHSN268201100006C / NHLBI NIH HHS HHSN268201100009C / NHLBI NIH HHS R01 DK089174 / NIDDK NIH HHS HHSN268201100011C / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS HHSN268201100011I / NHLBI NIH HHS K24 DK106414 / NIDDK NIH HHS HHSN268201100007I / NHLBI NIH HHS HHSN268201100009I / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000382422200009
- Scopus ID
- 2-s2.0-84985896490
- Other Identifier
- 991020550338804721
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- Domestic collaboration
- Web of Science research areas
- Medical Laboratory Technology