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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Alcohol-induced dysregulation of stress-related circuitry: The search for novel targets and implications for interventions across the sexes
Progress in neuro-psychopharmacology & biological psychiatry, v 65, pp 252-259
04 Feb 2016
PMID: 26006055
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
While the ability to process fermented fruits and alcohols was once an adaptive trait that improved nutrition and quality of life, the availability and prevalence of high potency alcoholic drinks has contributed to alcohol abuse disorders in a vulnerable portion of the population. Although the neural reward systems take part in the initial response to alcohol, negative reinforcement and stress, which are normally adaptive responses, can intersect to promote continued alcohol use at all stages of the addiction cycle. Eventually a point is reached where these once adaptive responses become dysregulated resulting in uncontrolled intake that constitutes a clinically important condition termed alcohol use disorder (AUD). Current research is targeted at both the behavioral and molecular adaptations in AUDs in an effort to better develop novel approaches to intervention. In this review, historical context is provided demonstrating the societal burden of alcohol use and abuse disorders. The importance of gender in the mechanism of action of alcohol is discussed. Finally, the impact of alcohol on stress-related circuitry, uncovered by preclinical research, is outlined to provide insight into potential novel pharmacological approaches to the treatment of AUD.
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Details
- Title
- Alcohol-induced dysregulation of stress-related circuitry: The search for novel targets and implications for interventions across the sexes
- Creators
- T.A. Retson - Center for NeurosciencesR.C. Sterling - Thomas Jefferson UniversityE.J. Van Bockstaele - Drexel University
- Publication Details
- Progress in neuro-psychopharmacology & biological psychiatry, v 65, pp 252-259
- Publisher
- Elsevier
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000366709200030
- Scopus ID
- 2-s2.0-84949535053
- Other Identifier
- 991021903291804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry