Journal article
Alcohol-induced salivary hyperamylasemia
The Journal of surgical research, v 36(4), pp 389-394
Apr 1984
PMID: 6200693
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effects of alcohol intoxication on serum amylase levels were tested in both normal subjects and chronic alcoholics. Paired samples of ethanol levels and isoamylase levels in the normal subjects (
n = 11) showed a rise in both total serum amylase (
P < 0.01) and nonpancreatic isoamylase (
P < 0.05) after drinking. Unpaired cohort groups of sober chronic alcoholics at a rehabilitation facility (
n = 46) and intoxicated chronic alcoholics in an emergency room (
n = 58) were also compared. Average blood alcohol levels in the intoxicated controls were 93 mg% compared to a level of 301 mg% in the intoxicated chronic alcoholic. Intoxication superimposed on chronic alcoholism caused a moderate rise in the total serum amylase (NS) and a significant elevation of the nonpancreatic isoamylase (
P < 0.01). Sober chronic alcoholics had a significantly greater average total serum amylase (
P < 0.001) and nonpancreatic isoamylase (
P < 0.01) than the normal controls. No difference in the average pancreatic isoamylase levels was seen in any group. These data suggest a biphasic response to alcohol on the serum amylase level. Acute and chronic changes appear to operate independently. The cause for these effects is speculative. Isoamylase analysis is needed in the alcoholic population to sort out the meaning of hyperamylasemia.
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Details
- Title
- Alcohol-induced salivary hyperamylasemia
- Creators
- Robert S. Bloch - Wayne State UniversityDonald W. Weaver - Detroit Receiving HospitalDavid L. Bouwman - Detroit Receiving HospitalGreg Berger - Wayne State University
- Publication Details
- The Journal of surgical research, v 36(4), pp 389-394
- Publisher
- Elsevier
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:A1984SP41200016
- Scopus ID
- 2-s2.0-0021207024
- Other Identifier
- 991021921172804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Surgery