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Alkenenitrile Transmissive Olefination: Synthesis of the Putative Lignan "Morinol I"
Journal article   Open access   Peer reviewed

Alkenenitrile Transmissive Olefination: Synthesis of the Putative Lignan "Morinol I"

Fraser F. Fleming, Wang Liu, Lihua Yao, Bhaskar Pitta, Matthew Purzycki and P. C. Ravikumar
European journal of organic chemistry, v 2011(34), pp 6843-6846
Dec 2011
PMID: 22545004
url
https://europepmc.org/articles/pmc3336159?pdf=renderView
Accepted (AM)Open Access (License Unspecified) Open

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Grignard reagents trigger an additionelimination with a'-hydroxy acrylonitriles to selectively generate Z-alkenenitriles. The modular assembly of Z-alkenenitriles from a Grignard reagent, acrylonitrile, and an aldehyde is ideal forstereoselectively synthesizing alkenes, as illustrated in the synthesis of the putative lignan morinol I.

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Domestic collaboration
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Web of Science research areas
Chemistry, Organic
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