Grignard reagents trigger an additionelimination with a'-hydroxy acrylonitriles to selectively generate Z-alkenenitriles. The modular assembly of Z-alkenenitriles from a Grignard reagent, acrylonitrile, and an aldehyde is ideal forstereoselectively synthesizing alkenes, as illustrated in the synthesis of the putative lignan morinol I.
Alkenenitrile Transmissive Olefination: Synthesis of the Putative Lignan "Morinol I"
Creators
Fraser F. Fleming - Duquesne University
Wang Liu - The Ohio State University
Lihua Yao - Duquesne University
Bhaskar Pitta - Duquesne University
Matthew Purzycki - Duquesne University
P. C. Ravikumar - Indian Institute of Technology Mandi
Publication Details
European journal of organic chemistry, v 2011(34), pp 6843-6846
Publisher
Wiley
Number of pages
4
Grant note
2R15AI051352-03 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
R15AI051352 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
0808996; 0614785; 024872; 0421252 / National Science Foundation; National Science Foundation (NSF)
Resource Type
Journal article
Language
English
Academic Unit
Chemistry
Web of Science ID
WOS:000297205800002
Scopus ID
2-s2.0-81855206130
Other Identifier
991020898499704721
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