Journal article
Alkenenitriles: Zn-Cu promoted conjugate additions of alkyl iodides in water
Organic letters, v 8(8), pp 1557-1559
13 Apr 2006
PMID: 16597109
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
[reaction: see text] A new silica-supported zinc-copper matrix dramatically promotes conjugate additions of alkyl iodides to alkenenitriles in water. Acyclic and cyclic nitriles react with functionalized alkyl iodides, overcoming the previous difficulty of performing conjugate additions to disubstituted alkenenitriles with nonstabilized carbon nucleophiles. Conjugate additions with omega-chloroalkyl iodides generate cyclic nitriles primed for cyclization, collectively providing one of the few annulation methods for cyclic alkenenitriles.
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Details
- Title
- Alkenenitriles: Zn-Cu promoted conjugate additions of alkyl iodides in water
- Creators
- Fraser F Fleming - Duquesne UniversitySubrahmanyam Gudipati - Duquesne University
- Publication Details
- Organic letters, v 8(8), pp 1557-1559
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000236950400012
- Scopus ID
- 2-s2.0-33646444563
- Other Identifier
- 991020898497704721
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- Web of Science research areas
- Chemistry, Organic