Journal article
Alkenenitriles: annulations with omega-chloro Grignard reagents
Organic letters, v 4(15), pp 2493-2495
25 Jul 2002
PMID: 12123359
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
[reaction: see text] omega-Chloro Grignard reagents chelate with cyclic gamma-hydroxy-alpha,beta-alkenenitriles to trigger a conjugate addition-alkylation annulation. The chelation-controlled conjugate addition-alkylation is the first anionic annulation with alpha, beta-alkenenitriles, providing cis bicyclo[3.3.0]octane, hydrindane, and decalin ring systems in a single synthetic operation.
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Details
- Title
- Alkenenitriles: annulations with omega-chloro Grignard reagents
- Creators
- Fraser F Fleming - Duquesne UniversityZhiyu ZhangQunzhao Wang - Duquesne UniversityOmar W Steward - Duquesne University
- Publication Details
- Organic letters, v 4(15), pp 2493-2495
- Publisher
- American Chemical Society; Washington, DC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000176938200012
- Scopus ID
- 2-s2.0-0038136138
- Other Identifier
- 991020898496904721
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- Web of Science research areas
- Chemistry, Organic