Journal article
Alleles of the rat T-cell receptor beta chain gene complex
Immunogenetics (New York), v 35(5), pp 324-331
1992
PMID: 1348495
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Inbred rat strains provide a rich source of genetic diversity in immunologically relevant genes. We have characterized the alleles of one of these genes, encoding the rat T-cell receptor C beta 1 chain, by Southern blots and nucleic acid sequencing. The Cb1 gene segments from DA and LEW rats display complex allotypic variation: both coding and noncoding regions contain multiple nucleotide substitutions. In addition, there is a polymorphic insertion of a rat repetitive LINE element 3' to the coding region. The Cb1 alleles are one part of larger Tcrb haplotypes, containing V beta, D beta, and J beta elements; complete Cb1 genomic nucleotide sequences, and a partial list of the strain distribution of the two alleles, are described in this report.
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Details
- Title
- Alleles of the rat T-cell receptor beta chain gene complex
- Creators
- E P Blankenhorn - Hahnemann University HospitalP D Smith - Hahnemann University HospitalC B Williams - University of California, IrvineG A Gutman - University of California, Irvine
- Publication Details
- Immunogenetics (New York), v 35(5), pp 324-331
- Publisher
- Springer Nature
- Grant note
- NS25519 / NINDS NIH HHS AI14774 / NIAID NIH HHS AI21366 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:A1992HM82400005
- Scopus ID
- 2-s2.0-0026530369
- Other Identifier
- 991019183989104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Genetics & Heredity
- Immunology