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Journal article
Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients with HIV
The journal of infectious diseases
11 Mar 2026
PMID: 41823991
Featured in Collection : Drexel's Newest Publications
Abstract
People with HIV-1 have higher risk for rejection after kidney transplantation but the mechanism is poorly understood. As HIV latency promotes immune dysregulation and chronic inflammation, we evaluated whether the size of the HIV latent viral reservoir (LVR) at baseline and through 52-weeks is associated with rejection in kidney transplant recipients with HIV from donors with and without HIV. Using the intact proviral DNA assay, we found no differences in the LVR between those who experienced rejection (n = 14) versus those who did not (N = 55) regardless of donor HIV status. These data support the feasibility of HIV+ to HIV+ organ transplantation.
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Details
- Title
- Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients with HIV
- Creators
- Karthik M Ranganna - Drexel University, Medicine (Graduate)
- Publication Details
- The journal of infectious diseases
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:001719560200001
- Other Identifier
- 991022170456704721