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Journal article
Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints
PloS one, v 11(6), pp e0156783-e0156783
2016
PMID: 27280771
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Osteoarthritis (OA) is one of most common skeletal disorders and can affect synovial joints such as knee and ankle joints. α5 integrin, a major fibronectin receptor, is expressed in articular cartilage and has been demonstrated to play roles in synovial joint development and in the regulation of chondrocyte survival and matrix degradation in articular cartilage. We hypothesized that α5 integrin signaling is involved in pathogenesis of OA. To test this, we generated compound mice that conditionally ablate α5 integrin in the synovial joints using the Gdf5Cre system. The compound mice were born normally and had an overall appearance similar to the control mice. However, when the mutant mice received the OA surgery, they showed stronger resistance to osteoarthritic changes than the control. Specifically the mutant knee joints presented lower levels of cartilage matrix and structure loss and synovial changes and showed stronger biomechanical properties than the control knee joints. These findings indicate that α5 integrin may not be essential for synovial joint development but play a causative role in induction of osteoarthritic changes.
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Details
- Title
- Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints
- Creators
- Maria Elena Candela - Children's Hospital of PhiladelphiaChao Wang - Drexel UniversityAruni T Gunawardena - Children's Hospital of PhiladelphiaKairui Zhang - Southern Medical UniversityLeslie Cantley - Children's Hospital of PhiladelphiaRika Yasuhara - Showa UniversityYu Usami - Children's Hospital of PhiladelphiaNoelle Francois - Children's Hospital of PhiladelphiaMasahiro Iwamoto - Children's Hospital of PhiladelphiaArjan van der Flier - Howard Hughes Medical InstituteYejia Zhang - University of PennsylvaniaLing Qin - University of PennsylvaniaLin Han - Drexel UniversityMotomi Enomoto-Iwamoto - Children's Hospital of Philadelphia
- Publication Details
- PloS one, v 11(6), pp e0156783-e0156783
- Publisher
- Public LIbrary of Science (PLOS)
- Grant note
- R01 AR062908 / NIAMS NIH HHS R01 AR061758 / NIAMS NIH HHS R01 AR046000 / NIAMS NIH HHS R21 AR066824 / NIAMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000377563000048
- Scopus ID
- 2-s2.0-84976325891
- Other Identifier
- 991019168867404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology