Journal article
Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level
American journal of Alzheimer's disease and other dementias, v 20(5), pp 315-318
01 Sep 2005
PMID: 16273997
Abstract
In central nervous system diseases, abnormal aggregation of one protein is often associated with aggregation of other proteins. To begin to assess whether beta-amyloid (Abeta) is associated with alpha-synuclein (AS) aggregation [secondary Lewy body (LB) formation], we used immunohistochemical techniques to compare the amygdala of 11 subjects with pathological aging and 18 with Alzheimer's disease. Overall, Abeta-40 plaque level was greater in cases with secondary AS aggregates. Abeta-42 plaque level was not associated with AS aggregation. Abeta-40 plaque levels cannot be ruled out as a factor involved in secondary LB formation.
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30 citations in Scopus
Details
- Title
- Alpha-Synuclein aggregation in pathological aging and Alzheimer's disease: the impact of beta-amyloid plaque level
- Creators
- Sara M Lippa - Drexel UniversityCarol F Lippa - Drexel UniversityHiroshi Mori - Osaka City University
- Publication Details
- American journal of Alzheimer's disease and other dementias, v 20(5), pp 315-318
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Scopus ID
- 2-s2.0-27144472378
- Other Identifier
- 991019312351004721