Journal article
Alterations in intrahepatic hemodynamics of the harvested porcine liver
Journal of gastrointestinal surgery, v 5(5), pp 490-498
01 Sep 2001
PMID: 11985999
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Abstract
Hemodynamic properties of a donor liver, during initial reperfusion, are associated with the degree of graft preservation injury and have been proposed to correlate with subsequent markers of liver function. In the present study, hepatic hemodynamics, that is, portal venous pressure, hepatic vascular resistance, and compliance (vascular distensibility), were characterized (1) in situ before porcine livers were manipulated, (2) after these same livers were isolated and perfused within a bypass circuit, and (3) on reperfusion after 2 hours of cold ischemia. Hepatic vascular resistance was determined in each of these three states from the portal vein pressure response to differing hepatic blood flows. In addition, the response of the same livers to norepinephrine and nitroprusside was evaluated in each condition. In the in situ and isolated perfused liver, portal venous pressure increased only modestly despite doubling of hepatic flows. After cold ischemia, the pressure response to higher flows was significantly greater and much less of a reduction in hepatic vascular resistance was noted than in studies prior to cold ischemia. Unlike livers prior to cold ischemia, the pressure response to norepinephrine was attenuated following cold ischemia. The response to nitroprusside, however, remained intact reducing the portal pressure to that of in situ livers. Therefore the portal hypertension that follows cold ischemia appears to be largely provoked by the preservation injury and not by surgical manipulation or the bypass circuit. This increment in portal pressure is responsive to a nitric oxide donor.
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Details
- Title
- Alterations in intrahepatic hemodynamics of the harvested porcine liver
- Creators
- Rocco Ricciardi - University of Massachusetts Chan Medical SchoolDavid P. FoleySteven H. QuarfordtRobin D. KimSusan E. DonohueSuzanne M. WheelerRavi S. ChariMark P. CalleryWilliam C. Meyers
- Publication Details
- Journal of gastrointestinal surgery, v 5(5), pp 490-498
- Publisher
- Elsevier
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000171576100008
- Scopus ID
- 2-s2.0-0035468620
- Other Identifier
- 991021937748704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology
- Surgery