Journal article
Altered functional connectivity of the thalamus induced by modified electroconvulsive therapy for schizophrenia
Schizophrenia research, v 218, pp 209-218
01 Apr 2020
PMID: 31956007
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Abstract
Background: Electroconvulsive therapy (ECT) has been shown to be effective in schizophrenia (SZ), particularly in drug-refractory cases or when rapid symptom relief is needed. However, its precise mechanisms of action remain largely unclear.To clarify the mechanisms underlying modified electroconvulsive therapy (mECT) for SZ, we conducted a longitudinal cohort study evaluating functional connectivity of the thalamus before and after mECT treatment using sub-regions of thalamus as regions of interest (ROIs).
Methods: Twenty-one SZ individuals taking only antipsychotics (DSZ group) for 4 weeks and 21 SZ patients receiving a regular course of mECT combining with antipsychotics (MSZ group) were observed in parallel. All patients underwent magnetic resonance imaging scans at baseline (t1) and follow-up (t2, similar to 4 weeks) time points. Data were compared to a matched healthy control group (HC group) consisting of 23 persons who were only scanned at baseline. Group differences in changes of thalamic functional connectivity between two SZ groups over time, as well as in functional connectivity among two SZ groups and HC group were assessed.
Results: Significant interaction of group by time was found in functional connectivity of the right thalamus to right putamen during the course of about 4-week treatment. Post-hoc analysis showed a significantly enhanced functional connectivity of the right thalamus to right putamen in the MSZ group contrasting to the DSZ group. In addition, a decreased and an increased functional connectivity of the thalamus to sensory cortex were observed within the MSZ and DSZ group after 4-week treatment trial, respectively.
Conclusion: Our findings suggest that changes in functional connectivity of the thalamus may be associated with the brain mechanisms of mECT for schizophrenia. (C) 2019 Published by Elsevier B.V.
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Details
- Title
- Altered functional connectivity of the thalamus induced by modified electroconvulsive therapy for schizophrenia
- Creators
- Junjie Wang - Soochow Univ, Affiliated Guangji Hosp, Inst Mental Hlth, Suzhou Guangji Hosp, Suzhou 215137, Jiangsu, Peoples R ChinaYuchao Jiang - University of Electronic Science and Technology of ChinaYingying Tang - Shanghai Mental Health CenterMengqing Xia - Shanghai Mental Health CenterAdrian Curtin - Shanghai Jiao Tong UniversityJin Li - Shanghai Mental Health CenterJianhua Sheng - Shanghai Mental Health CenterTianhong Zhang - Shanghai Mental Health CenterChunbo Li - Shanghai Mental Health CenterLi Hui - Suzhou Guangji HospitalHongliang Zhu - Suzhou Guangji HospitalBharat B. Biswal - University of Electronic Science and Technology of ChinaQiufang Jia - Suzhou Guangji HospitalCheng Luo - University of Electronic Science and Technology of ChinaJijun Wang - Shanghai Mental Health Center
- Publication Details
- Schizophrenia research, v 218, pp 209-218
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- 81361120403; 81671332; 81671329; 81871050 / National Nature Science Foundation of China; National Natural Science Foundation of China (NSFC) lczx201515 / Key Diagnosis and Treatment program of Suzhou 16JC1420200; 17411953100 / Shanghai Science and Technology Committee, China; Shanghai Science & Technology Committee 2016YFC1306800 / Ministry of Science and Technology of China, National Key Research and Development Program of China 2017YQ069 / Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai 17ZR1424700 / Natural Science Foundation of Shanghai, China; Natural Science Foundation of Shanghai sys2018097 / Suzhou Municipal Science and Technology Bureau, China CRC2018ZD01; CRC2018ZD04; CRC2018YB01; CRC2019ZD02 / Clinical Research Center at Shanghai Mental Health Center
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000541708500029
- Scopus ID
- 2-s2.0-85077920163
- Other Identifier
- 991019168508504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry