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Journal article
Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa
Psychological medicine, v 25(8), pp 3580-3590
25 Jun 2023
PMID: 35209961
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: The sense of 'loss of control' (LOC), or a feeling of being unable to stop eating or control what or how much one is eating, is the most salient aspect of binge eating. However, the neural alterations that may contribute to this experience and eating behavior remain poorly understood.
Methods: We used functional near-infrared spectroscopy (fNIRS) to measure activation in the prefrontal cortices of 23 women with bulimia nervosa (BN) and 23 healthy controls (HC) during two tasks: a novel go/no-go task requiring inhibition of eating responses, and a standard go/no-go task requiring inhibition of button-pressing responses.
Results: Women with BN made more commission errors on both tasks. BN subgroups with the most severe LOC eating (n = 12) and those who felt most strongly that they binge ate during the task (n = 12) showed abnormally reduced bilateral ventromedial prefrontal cortex (vmPFC) and right ventrolateral prefrontal cortex (vlPFC) activation associated with eating-response inhibition. In the entire BN sample, lower eating-task activation in right vlPFC was related to more frequent and severe LOC eating, but no group differences in activation were detected on either task when this full sample was compared with HC. BN severity was unrelated to standard-task activation.
Conclusions: Results provide initial evidence that diminished PFC activation may directly contribute to more severe eating-specific control deficits in BN. Our findings support vmPFC and vlPFC dysfunction as promising treatment targets, and indicate that eating-specific tasks and fNIRS may be useful tools for identifying neural mechanisms underlying dysregulated eating.
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Details
- Title
- Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa
- Creators
- Laura A. Berner (Corresponding Author) - Icahn School of Medicine at Mount SinaiSamantha R. Winter - Google (United States)Hasan Ayaz - Drexel UniversityPatricia A. Shewokis - Drexel UniversityMeltem Izzetoglu - Villanova UniversityRachel Marsh - Columbia UniversityJennifer A. Nasser - Drexel UniversityAlyssa J. Matteucci - University of PennsylvaniaMichael R. Lowe - Drexel University
- Publication Details
- Psychological medicine, v 25(8), pp 3580-3590
- Publisher
- Cambridge Univ Press
- Number of pages
- 11
- Grant note
- F31MH097406 / National Institute of Mental Health fellowship; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) American Psychological Association Dissertation Research Award Academy for Eating Disorders Student Research Grant
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology); School of Biomedical Engineering, Science, and Health Systems; Nutrition Sciences
- Web of Science ID
- WOS:000760934600001
- Scopus ID
- 2-s2.0-85125526978
- Other Identifier
- 991019168574404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Psychiatry
- Psychology
- Psychology, Clinical