Journal article
Altered sensitivity to footshock after selective serotonin depletion: Comparison of electrolytic lesions and neurotoxin injections in the medial forebrain bundle of the rat
Journal of comparative & physiological psychology, v 95(2), pp 341-350
Apr 1981
PMID: 6971883
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Abstract
Compared the changes in 183 male albino rats' jump threshold with changes in monoamine content of the telencephalon after damage to the lateral hypothalamus produced either by electrolytic lesions or by 6-hydroxydopamine (6-OHDA) and 5,7-dihydroxytryptamine (DHT). Electrolytic lesions produced significant decreases in jump threshold and in telencephalic content of serotonin, norepinephrine, and dopamine. Infusions of DHT, with or without pretreatment with desipramine, always reduced both jump thresholds and serotonin content, even when there was no effect on norepinephrine or dopamine. In contrast, 6-OHDA had no effect on jump thresholds or serotonin content, even though both norepinephrine and dopamine were greatly reduced. Results suggest that the increased sensitivity to footshock was solely due to the interruption of ascending serotonergic pathways within the lateral hypothalamus and was not a result of damage either to norepinephrine and dopamine pathways or to some other neural system. (26 ref)
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Details
- Title
- Altered sensitivity to footshock after selective serotonin depletion: Comparison of electrolytic lesions and neurotoxin injections in the medial forebrain bundle of the rat
- Creators
- Kenny J Simansky - New York Hosp-Cornell Medical Ctr, Edward W. Bourne Behavioral Research Lab, White PlainsJohn A Harvey
- Publication Details
- Journal of comparative & physiological psychology, v 95(2), pp 341-350
- Publisher
- American Psychological Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration
- Web of Science ID
- WOS:A1981LL31900014
- Scopus ID
- 2-s2.0-0019556724
- Other Identifier
- 991021842661504721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Psychology, Biological