Journal article
Altered vasopressin and natriuretic peptide levels in a rat model of spinal cord injury: implications for the development of polyuria
American journal of physiology. Renal physiology, v 314(1), pp F58-F66
01 Jan 2018
PMID: 28877880
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Urinary dysfunction is a common complaint following spinal cord injury (SCI) and is a leading issue for individuals with SCI that impacts their quality of life. One urinary complication that has received little attention is SCI-induced polyuria, even though individuals with SCI will significantly restrict their fluid intake to decrease urine production, leading to sequelae of medical complications. Understanding the mechanisms instigating the development of polyuria will allow us to target interventions that may alleviate polyuria symptoms, leading to significant improvements in the quality of life and urinary health of individuals with SCI. In a rat SCI contusion model, an increase in the amount of urine excreted over a 24-h period ( P ≤ 0.001) was found at 2 wk postinjury. The urine excreted was more dilute with decreased urinary creatinine and specific gravity ( P ≤ 0.001). Several factors important in fluid balance regulation, vasopressin (AVP), natriuretic peptides, and corticosterone (CORT), also changed significantly postinjury. AVP levels decreased ( P = 0.042), whereas atrial natriuretic peptide (ANP) and CORT increased ( P = 0.005 and P = 0.031, respectively) at 2 wk postinjury. There was also a positive correlation between the increase in ANP and urine volume postinjury ( P = 0.033). The changes in AVP, ANP, and CORT are conducive to producing polyuria, and the timing of these changes coincides with the development of SCI-induced polyuria. This study identifies several therapeutic targets that could be used to ameliorate polyuria symptoms and improve quality of life in individuals with SCI.
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Details
- Title
- Altered vasopressin and natriuretic peptide levels in a rat model of spinal cord injury: implications for the development of polyuria
- Creators
- Lynnette R Montgomery - University of LouisvilleCharles H Hubscher - University of Louisville
- Publication Details
- American journal of physiology. Renal physiology, v 314(1), pp F58-F66
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:000423469900006
- Scopus ID
- 2-s2.0-85043532848
- Other Identifier
- 991021866822204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Physiology
- Urology & Nephrology