Journal article
Alzheimer's Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-beta with Regard to Potential Treatment and Prevention
Journal of Alzheimer's disease, v 53(4), pp 1271-1276
01 Jan 2016
PMID: 27372648
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Alzheimer's disease (AD) is an infectious disease caused by spirochetes, and these spirochetes form biofilms, which attract the innate immune system. The innate immune system first responder, Toll-like receptor 2, generates both NF-kappa B and TNF-alpha which try to kill the spirochetes in the biofilm, but cannot penetrate the "slime". NF-kappa B is also responsible for the generation of amyloid-beta (A beta) which itself is anti-microbial. A beta cannot penetrate the biofilm either, and its accumulation leads to destruction of the cerebral neurocircuitry. Treatment with penicillin (as in tertiary syphilis, the comparator to AD) is outlined; a biofilm dispersing agent may need to be added to the protocol.
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Details
- Title
- Alzheimer's Disease: Assessing the Role of Spirochetes, Biofilms, the Immune System, and Amyloid-beta with Regard to Potential Treatment and Prevention
- Creators
- Herbert B. Allen - Drexel University
- Publication Details
- Journal of Alzheimer's disease, v 53(4), pp 1271-1276
- Publisher
- Ios Press
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000383149600003
- Scopus ID
- 2-s2.0-84981719347
- Other Identifier
- 991019319092804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences