Journal article
Alzheimer's Disease Is a Multi-Organ Disorder: It May Already Be Preventable
Journal of Alzheimer's disease, v 90(4), pp 1277-1281
01 Jan 2023
PMID: 36617785
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In this commentary, we offer an overview of the several environmental and metabolic factors that have been identified as contributing to the development of Alzheimer's disease (AD). Many of these factors involve extracranial organ systems including immune system dysfunction accompanied by neuroinflammation (inflammaging), gastrointestinal dysbiosis, insulin resistance, and hepatic dysfunction. A variety of microbial factors including mouth flora, viruses, and fungi appear to play a significant role. There is a role for the colonic microbiome becoming dysbiotic and producing toxic metabolites. Declining hepatic function contributes diminished neuronal precursors and reduces toxin elimination. Environmental toxins especially metals play an important role in impairing the blood-brain barrier and acting synergistically with biotoxins and other toxic chemicals. Prevention and treatment of AD appears to require measuring several of these biomarkers and implementing corrective actions regarding such toxicants and correcting metabolic dysfunction at early or preclinical stages of this disorder.
Metrics
Details
- Title
- Alzheimer's Disease Is a Multi-Organ Disorder: It May Already Be Preventable
- Creators
- Arnold R. Eiser - University of PennsylvaniaTamas Fulop - Université de Sherbrooke
- Publication Details
- Journal of Alzheimer's disease, v 90(4), pp 1277-1281
- Publisher
- Ios Press
- Number of pages
- 5
- Grant note
- P30 ES013508 / National Institute of Environmental Health Sciences (NIEHS), NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000939222800005
- Scopus ID
- 2-s2.0-85148678201
- Other Identifier
- 991021930440804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences