Journal article
Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City
Environmental health perspectives, v 124(8), pp 1283-1290
01 Aug 2016
PMID: 26862865
Abstract
BACKGROUND: Recent studies have suggested associations between air pollution and various birth outcomes, but the evidence for preterm birth is mixed. Objective: We aimed to assess the relationship between air pollution and preterm birth using 2008-2010 New York City (NYC) birth certificates linked to hospital records.
METHODS: We analyzed 258,294 singleton births with 22-42 completed weeks gestation to nonsmoking mothers. Exposures to ambient fine particles (PM2.5) and nitrogen dioxide (NO2) during the first, second, and cumulative third trimesters within 300 m of maternal address were estimated using data from the NYC Community Air Survey and regulatory monitors. We estimated the odds ratio (OR) of spontaneous preterm (gestation < 37 weeks) births for the first-and secondtrimester exposures in a logistic mixed model, and the third-trimester cumulative exposures in a discrete time survival model, adjusting for maternal characteristics and delivery hospital. Spatial and temporal components of estimated exposures were also separately analyzed.
RESULTS: PM2.5 was not significantly associated with spontaneous preterm birth. NO2 in the second trimester was negatively associated with spontaneous preterm birth in the adjusted model (OR = 0.90; 95% CI: 0.83, 0.97 per 20 ppb). Neither pollutant was significantly associated with spontaneous preterm birth based on adjusted models of temporal exposures, whereas the spatial exposures showed significantly reduced odds ratios (OR = 0.80; 95% CI: 0.67, 0.96 per 10 mu g/m(3) PM2.5 and 0.88; 95% CI: 0.79, 0.98 per 20 ppb NO2). Without adjustment for hospital, these negative associations were stronger.
CONCLUSION: Neither PM2.5 nor NO2 was positively associated with spontaneous preterm delivery in NYC. Delivery hospital was an important spatial confounder.
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Details
- Title
- Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City
- Creators
- Sarah Johnson - New York City Department of Health and Mental HygieneJennifer F. Bobb - Biostat (United States)Kazuhiko Ito - New York City Dept Hlth & Mental Hyg, New York, NY USADavid A. Savitz - Brown UniversityBeth Elston - Brown UniversityJessie L. C. Shmool - University of PittsburghFrancesca Dominici - Biostat (United States)Zev Ross - ZevRoss Spatial Anal, Ithaca, NY USAJane E. Clougherty - University of PittsburghThomas Matte - New York City Dept Hlth & Mental Hyg, New York, NY USA
- Publication Details
- Environmental health perspectives, v 124(8), pp 1283-1290
- Publisher
- Us Dept Health Human Sciences Public Health Science
- Number of pages
- 8
- Grant note
- 1R01-ES019955-01 / National Institute of Environmental Health Sciences, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) T32ES007142 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Dana and David Dornsife School of Public Health; Drexel University; Environmental and Occupational Health
- Web of Science ID
- WOS:000380749900028
- Scopus ID
- 2-s2.0-84980398190
- Other Identifier
- 991020099991904721
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