Journal article
American Brachytherapy Society Task Group Report: Long-term control and toxicity with brachytherapy for localized breast cancer
Brachytherapy, v 16(1), pp 13-21
01 Jan 2017
PMID: 27288156
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There has been significant controversy regarding the equivalency of accelerated partial breast irradiation to whole-breast irradiation. With the recent publication of a large, randomized trial comparing these two treatment modalities, an update on the current state of knowledge of brachytherapy-based accelerated partial breast irradiation, with respect to local control and toxicities, would be useful to practitioners and patients.
A systematic literature review was conducted examining articles published between January 2000 and April 2016 on the topics “brachytherapy” and “breast.” A total of 67 articles met inclusion criteria, providing outcomes on local tumor control and/or toxicity for breast brachytherapy.
Reported 5-year local failure rates were 1.4–6.1% for multicatheter interstitial brachytherapy (MIB) and 0–5.7% for single-entry brachytherapy catheters when delivered to patients with standard selection criteria. Toxicity profiles are acceptable, with cosmetic outcomes comparable to whole-breast irradiation. The reported rates of infection were 0–12%. Symptomatic fat necrosis was found in 0–12% and 0–3.2% of patients treated with MIB and single-entry brachytherapy catheters, respectively. Late Grade ≥3 telangiectasias and fibrosis were reported in 0–8% and 0–9.1% of patients treated with MIB, respectively. These side effects were less common with single-entry brachytherapy catheters (0–2.0% and 0%, respectively).
Breast brachytherapy is a treatment technique that provides acceptable rates of local control in select patients, as demonstrated by Level I evidence. The side effect profile of this treatment is well documented and should be shared with patients when considering this treatment modality.
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Details
- Title
- American Brachytherapy Society Task Group Report: Long-term control and toxicity with brachytherapy for localized breast cancer
- Creators
- Simona F. Shaitelman - The University of Texas MD Anderson Cancer CenterBeatriz Amendola - Innovative Cancer Institute, South Miami, FLAtif Khan - Rutgers Cancer Institute of New JerseySushil Beriwal - University of PittsburghRachel Rabinovitch - University of Colorado DenverD. Jeffrey Demanes - University of California, Los AngelesLeonard H. Kim - Cooper University HospitalLaurie Cuttino - Virginia Commonwealth University
- Publication Details
- Brachytherapy, v 16(1), pp 13-21
- Publisher
- Elsevier
- Grant note
- Elekta
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000392793900002
- Scopus ID
- 2-s2.0-84973520067
- Other Identifier
- 991021897263904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging