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American Heart Association's Life's Simple 7 and risk of venous thromboembolism: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study
Journal article   Open access

American Heart Association's Life's Simple 7 and risk of venous thromboembolism: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study

Nels C Olson, Mary Cushman, Suzanne E Judd, Leslie A McClure, Susan G Lakoski, Aaron R Folsom, Monika M Safford and Neil A Zakai
Journal of the American Heart Association, v 4(3), pp e001494-e001494
27 Feb 2015
DOI: https://doi.org/10.1161/JAHA.114.001494
PMID: 25725088
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1161/jaha.114.001494View
Published, Version of Record (VoR)CC BY-NC-ND V4.0,  Open
url
https://doi.org/10.1161/JAHA.114.001494View
Published, Version of Record (VoR) Open

Abstract

Aged American Heart Association Female Health Status Health Status Indicators Humans Incidence Life Style - ethnology Male Middle Aged Prognosis Prospective Studies Residence Characteristics Risk Factors Risk Reduction Behavior Socioeconomic Factors Stroke - diagnosis Stroke - ethnology Stroke - prevention & control Time Factors United States - epidemiology Venous Thromboembolism - diagnosis Venous Thromboembolism - ethnology Venous Thromboembolism - prevention & control
The American Heart Association's Life's Simple 7 metric is being used to track the population's cardiovascular health (CVH) toward a 2020 goal for improvement. The metric includes body mass index (BMI), blood pressure, cholesterol, glucose, physical activity (PA), cigarette smoking, and diet. We hypothesized a lower risk of venous thromboembolism (VTE) with favorable Life's Simple 7 scores. REGARDS recruited 30,239 black and white participants ≥45 years of age across the United States in 2003-2007. A 14-point summary score for Life's Simple 7 classified participants into inadequate (0 to 4 points), average (5 to 9 points), and optimal (10 to 14 points) categories. Hazard ratios (HRs) of incident VTE were calculated for these categories, adjusting for age, sex, race, income, education, and region of residence. For comparison, HRs of VTE were calculated using the Framingham 10-year coronary risk score. There were 263 incident VTE cases over 5.0 years of follow-up; incidence rates per 1000 person-years declined from 2.9 (95% confidence interval [CI], 2.3 to 3.7) among those in the inadequate category to 1.8 (95% CI, 1.4 to 2.4) in the optimal category. Compared to the inadequate category, participants in the average category had a 38% lower VTE risk (95% CI, 11 to 57) and participants in the optimal category had a 44% lower risk (95% CI, 18 to 62). The individual score components related to lower VTE risk were ideal PA and BMI. There was no association of Framingham Score with VTE. Life's Simple 7, a CVH metric, was associated with reduced VTE risk. Findings suggest that efforts to improve the population's CVH may reduce VTE incidence.

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64 citations in Web of Science
63 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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