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Among pregnant women with bacterial vaginosis, the hydrolytic enzymes sialidase and prolidase are positively associated with interleukin-1β
Journal article   Peer reviewed

Among pregnant women with bacterial vaginosis, the hydrolytic enzymes sialidase and prolidase are positively associated with interleukin-1β

Sabina Cauci, Jennifer Flatow Culhane, Manuela Di Santolo and Kelly McCollum
American journal of obstetrics and gynecology, v 198(1), pp 132.e1-132.e7
2008
DOI: https://doi.org/10.1016/j.ajog.2007.05.035
PMID: 17714681
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

bacterial vaginosis clue cells interleukin-1β interleukin-8 neutrophils pregnancy prolidase sialidase vaginal innate immunity
The objective of the study was to explore the mechanisms of local innate immunity induction and modulation in pregnant women with bacterial vaginosis (BV). A total of 200 singleton pregnant women in early gestation (12 ± 4 weeks) with BV (Nugent 7-10) without concurrent vaginal infections with Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, syphilis, and yeast. Concentrations of vaginal interleukin (IL)-1β and IL-8, the number of neutrophils, and the levels of sialidase and prolidase hydrolytic enzymes were determined in vaginal fluid. Concentrations of vaginal IL-1β had a strong positive correlation with levels of sialidase ( P < .001) and prolidase ( P < .001). Conversely, such enzymes were negatively correlated with the ratio of IL-8/IL-1β (both P < .001) and were not significantly associated with concentrations of IL-8. Notably, the number of vaginal neutrophils had a negative correlation with sialidase ( P = .007). The strong induction of IL-1β in BV-positive women appears to be associated with the production of the hydrolytic enzymes sialidase and prolidase by BV-associated bacteria. However, these 2 enzymes may inhibit the expected amplification of the proinflammatory IL-1β cascade as evaluated by the down-regulation of the IL-8/IL-1β ratio. A blunted response to IL-1β signals may cause the poor rise of neutrophils, which is peculiar to BV. This impairment of local defense may contribute to increased susceptibility to adverse outcomes in BV-positive pregnant women.

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Obstetrics & Gynecology
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