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Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress
Journal article   Open access   Peer reviewed

Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress

T A Retson, J B Hoek, R C Sterling and E J Van Bockstaele
Brain structure & function, v 220(6), pp 3211-3232
01 Nov 2015
DOI: https://doi.org/10.1007/s00429-014-0851-4
PMID: 25081549
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc4312755View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Alcoholism - metabolism Alcoholism - pathology Alcoholism - physiopathology Alcoholism - psychology Animals Central Amygdaloid Nucleus - drug effects Central Amygdaloid Nucleus - metabolism Central Amygdaloid Nucleus - physiology Corticotropin-Releasing Hormone - metabolism Disease Models, Animal Ethanol - toxicity Female Male Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Sex Factors Stress, Physiological - physiology
Alcohol abuse and alcoholism are major medical problems affecting both men and women. Previous animal studies reported a difference in c-Fos neuronal activation after chronic alcohol exposure; however, females remain an understudied population. To model chronic alcohol exposure match-pair fed adult male and female rats were administered 14 days of a liquid ethanol containing diet. Analysis focused on the central nucleus of the amygdala (CeA), a region integral to stress sensitivity and substance abuse. Immunocytochemical approaches identified cells containing ΔFosB, a marker of sustained neuronal activation, and activity patterns within the CeA were mapped by subdivision and rostral-caudal extent. Significant interactions were present between all groups, with gender differences noted among control groups, and ethanol exposed animals having the greatest number of ΔFosB immunoreactive cells indicating baseline dysregulation. Compared with c-Fos, a marker of recent neuronal activation, male ethanol treated animals had similar activity to controls, indicating a neuronal habituation not seen in females. Next, a cohort of animals were exposed to the forced swim test (FST), and c-Fos was examined in addition to FST behavior. Neuronal activity was increased in ethanol exposed animals compared to controls, and control females compared to males, indicating a potentiated stress response. Further, a population of activated neurons were shown to contain either corticotropin releasing factor or enkephalin. The present data suggest that dysregulation in the CeA neuronal activity may underlie some of the negative sequelae of alcohol abuse, and may, in part, underlie the distinctive response seen between genders to alcohol use.

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26 citations in Web of Science
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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Anatomy & Morphology
Neurosciences
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