Journal article
An Additional Role for the Outer Nuclear Membrane in the Morphogenesis of Herpes Simplex Virus
Intervirology, v 13(5), pp 312-316
01 Jan 1980
PMID: 6250993
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ultrastructural study of MRC-5 cells infected by herpes simplex virus yielded several examples of physical continuity between the outer nuclear membrane and the envelope of viral particles in the perinuclear cisterna, suggesting a fusion between the two. Such virions would thus lose their envelope and enter the cytoplasm as naked capsids. Fusion first occurred at 6–8 h postinfection (p.i.), while naked cytoplasmic capsids appeared at 6 h p.i. Since nuclear membrane disruption was not observed until 24 h p.i., it is unlikely to account for the early appearance of these capsids. Thus, in addition to its other roles, the outer nuclear membrane may be involved in naked cytoplasmic capsid production via a fusion event.
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Details
- Title
- An Additional Role for the Outer Nuclear Membrane in the Morphogenesis of Herpes Simplex Virus
- Creators
- Janet Duyckinck Smith
- Publication Details
- Intervirology, v 13(5), pp 312-316
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1980KD55100008
- Scopus ID
- 2-s2.0-0018889456
- Other Identifier
- 991021900027004721
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- Web of Science research areas
- Virology