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Journal article
An Association of Pathogens and Biofilms with Alzheimer's Disease
Microorganisms (Basel), v 10(1), p56
01 Jan 2022
PMID: 35056505
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
As one of the leading causes of dementia, Alzheimer's disease (AD) is a condition in which individuals experience progressive cognitive decline. Although it is known that beta-amyloid (A beta) deposits and neurofibrillary tangles (NFT) of tau fibrils are hallmark characteristics of AD, the exact causes of these pathologies are still mostly unknown. Evidence that infectious diseases may cause AD pathology has been accumulating for decades. The association between microbial pathogens and AD is widely studied, and there are noticeable correlations between some bacterial species and AD pathologies, especially spirochetes and some of the oral microbes. Borrelia burgdorferi has been seen to correlate with A beta plaques and NFTs in infected cells. Because of the evidence of spirochetes in AD patients, Treponema pallidum and other oral treponemes are speculated to be a potential cause of AD. T. pallidum has been seen to form aggregates in the brain when the disease disseminates to the brain that closely resemble the A beta plaques of AD patients. This review examines the evidence as to whether pathogens could be the cause of AD and its pathology. It offers novel speculations that treponemes may be able to induce or correlate with Alzheimer's disease.
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Details
- Title
- An Association of Pathogens and Biofilms with Alzheimer's Disease
- Creators
- Sandhya T. Chakravarthi - Drexel Univ, Coll Med, Ctr Surg Infect & Biofilm, Philadelphia, PA 19104 USASuresh G. Joshi - Drexel Univ, Coll Med, Ctr Surg Infect & Biofilm, Philadelphia, PA 19104 USA
- Publication Details
- Microorganisms (Basel), v 10(1), p56
- Publisher
- Mdpi
- Number of pages
- 18
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000746997200001
- Scopus ID
- 2-s2.0-85121670311
- Other Identifier
- 991019167688404721
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- Web of Science research areas
- Microbiology