Journal article
An Emerging Role for Ubiquilin 1 in Regulating Protein Quality Control System and in Disease Pathogenesis
Discovery medicine, Vol.8(40), pp.18-22
01 Jun 2009
PMCID: PMC3158983
PMID: 19772837
Abstract
The process of refolding or degrading misfolded proteins is the most important function of protein quality control (PQC) system. An imbalance between the capacity of PQC system and the quantity and severity of misfolded proteins may result in protein aggregate accumulation, which can ultimately contribute to a class of diseases referred to as conformational disorders. Numerous lines of evidence suggest that Ubiquilin 1 is an important component in PQC. Ubiquilin 1 has been indicated to be involved in the pathophysiology of neurodegenerative diseases and cancer. Here we review the evidence that Ubiquilin 1 is an important component of the PQC system and also review the role of Ubiquilin 1 in human diseases.
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Details
- Title
- An Emerging Role for Ubiquilin 1 in Regulating Protein Quality Control System and in Disease Pathogenesis
- Creators
- Can Zhang - Drexel UniversityAleister J. Saunders - Drexel University
- Publication Details
- Discovery medicine, Vol.8(40), pp.18-22
- Grant note
- R01 NS057295-02 || NS / National Institute of Neurological Disorders and Stroke : NINDS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Identifiers
- 991021448063104721