Journal article
An Immunologic and Biomechanical Comparison of Polyether Ether Ketone-Zeolite and Polyether Ether Ketone Interbody Fusion Devices
Spine (Philadelphia, Pa. 1976), v 48(16), pp 1174-1180
15 Aug 2023
PMID: 37235799
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Study Design.A laboratory study comparing polyether ether ketone (PEEK)-zeolite and PEEK spinal implants in an ovine model. Objective.This study challenges a conventional spinal implant material, PEEK, to PEEK-zeolite using a nonplated cervical ovine model. Summary of Background Data.Although widely used for spinal implants due to its material properties, PEEK is hydrophobic, resulting in poor osseointegration, and elicits a mild nonspecific foreign body response. Zeolites are negatively charged aluminosilicate materials that are hypothesized to reduce this pro-inflammatory response when used as a compounding material with PEEK. Materials and Methods.Fourteen skeletally mature sheep were, each, implanted with one PEEK-zeolite interbody device and one PEEK interbody device. Both devices were packed with autograft and allograft material and randomly assigned to one of 2 cervical disc levels. The study involved 2 survival time points (12 and 26 weeks) and biomechanical, radiographic, and immunologic endpoints. One sheep expired from complications not related to the device or procedure. A biomechanical evaluation was based on measures of segmental flexibility, using 6 degrees of freedom pneumatic spine tester. Radiographic evaluation was performed using microcomputed tomography scans in a blinded manner by 3 physicians. Levels of the pro-inflammatory cytokines, interleukin (IL)-1 & beta;, IL-6, and tumor necrosis factor-alpha at the implant, were quantified using immunohistochemistry. Results.PEEK-zeolite and PEEK exhibited an equivalent range of motion in flexion extension, lateral bending, and axial torsion. A motion was significantly reduced for implanted devices at both time points as compared with native segments. Radiographic assessments of fusion and bone formation were similar for both devices. PEEK-zeolite exhibited lower levels of IL-1 & beta; (P = 0.0003) and IL-6 (P = 0.03). Conclusion.PEEK-zeolite interbody fusion devices provide initial fixation substantially equivalent to PEEK implants but exhibit a reduced pro-inflammatory response. PEEK-zeolite devices may reduce the chronic inflammation and fibrosis previously observed with PEEK devices.
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Details
- Title
- An Immunologic and Biomechanical Comparison of Polyether Ether Ketone-Zeolite and Polyether Ether Ketone Interbody Fusion Devices
- Creators
- Boyle C. Cheng - Allegheny Health NetworkIsaac Swink - Allegheny Health NetworkEdward J. McClain - Allegheny Health NetworkPraveer S. Vyas - Allegheny Health NetworkThomas Muzzonigro - Allegheny Health NetworkJake Carbone - Allegheny Health NetworkAli Zaidi - Allegheny Hlth Network Res Inst, Pittsburgh, PA USAJason D. Long - Allegheny Hlth Network Res Inst, Pittsburgh, PA USADaniel T. Altman - Allegheny Health NetworkAlexander K. Yu - Allegheny Health Network
- Publication Details
- Spine (Philadelphia, Pa. 1976), v 48(16), pp 1174-1180
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Orthopedic/Orthopaedic Surgery; Surgery; Neurosurgery
- Web of Science ID
- WOS:001039202100010
- Scopus ID
- 2-s2.0-85166363112
- Other Identifier
- 991021897406404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Orthopedics