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Journal article
An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis
Science translational medicine, v 5(195)
24 Jul 2013
PMID: 23884467
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sepsis is a common cause of death, but outcomes in individual patients are difficult to predict. Elucidating the molecular processes that differ between sepsis patients who survive and those who die may permit more appropriate treatments to be deployed. We examined the clinical features and the plasma metabolome and proteome of patients with and without community-acquired sepsis, upon their arrival at hospital emergency departments and 24 hours later. The metabolomes and proteomes of patients at hospital admittance who would ultimately die differed markedly from those of patients who would survive. The different profiles of proteins and metabolites clustered into the following groups: fatty acid transport and beta-oxidation, gluconeogenesis, and the citric acid cycle. They differed consistently among several sets of patients, and diverged more as death approached. In contrast, the metabolomes and proteomes of surviving patients with mild sepsis did not differ from survivors with severe sepsis or septic shock. An algorithm derived from clinical features together with measurements of five metabolites predicted patient survival. This algorithm may help to guide the treatment of individual patients with sepsis.
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Details
- Title
- An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis
- Creators
- Raymond J. g Langley - National Center for Genome ResourcesEphraim L. Tsalik - Durham VA Medical CenterJennifer C. van Velkinburgh - National Center for Genome ResourcesSeth W. Glickman - University of North Carolina at Chapel HillBrandon J. Rice - National Center for Genome ResourcesChunping Wang - Duke UniversityBo Chen - Duke UniversityLawrence Carin - Duke UniversityArturo Suarez - Henry Ford HospitalRobert P. Mohney - Metabolon (United States)Debra H. Freeman - Duke UniversityMu Wang - Monarch Media (United States)Jinsam You - Monarch Media (United States)Jacob Wulff - Metabolon (United States)J. Will Thompson - Duke UniversityM. Arthur Moseley - Duke UniversityStephanie Reisinger - United BioSource Corp, Harrisburg, PA 17101 USABrian T. Edmonds - Eli Lilly (United States)Brian Grinnell - Eli Lilly (United States)David R. Nelson - Eli Lilly (United States)Darrell L. Dinwiddie - National Center for Genome ResourcesNeil A. Miller - National Center for Genome ResourcesCarol J. Saunders - Children's Mercy HospitalSarah S. Soden - Children's Mercy HospitalAngela J. Rogers - Brigham and Women's HospitalLee Gazourian - Brigham and Women's HospitalLaura E. Fredenburgh - Brigham and Women's HospitalAnthony F. Massaro - Brigham and Women's HospitalRebecca M. Baron - Brigham and Women's HospitalAugustine M. K. Choi - Brigham and Women's HospitalG. Ralph Corey - Duke UniversityGeoffrey S. Ginsburg - Duke UniversityCharles B. Cairns - University of North Carolina at Chapel HillRonny M. Otero - Henry Ford HospitalVance G. Fowler - Duke UniversityEmanuel P. Rivers - Henry Ford HospitalChristopher W. Woods - Durham VA Medical CenterStephen F. Kingsmore - National Center for Genome Resources
- Publication Details
- Science translational medicine, v 5(195)
- Publisher
- Amer Assoc Advancement Science
- Number of pages
- 17
- Grant note
- Pfizer Inc.; Pfizer U19HD077693 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) VA Career Development Award P20RR016480 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) U01AI066569 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) Agency for Healthcare Research and Quality; United States Department of Health & Human Services; Agency for Healthcare Research & Quality U01AI066569; P20RR016480; HHSN266200400064C; HL112747; HL05530 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Roche Diagnostics Inc R01HL055330 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) National Research Service Award training grant; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000322233400006
- Scopus ID
- 2-s2.0-84882977493
- Other Identifier
- 991021448184304721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Medicine, Research & Experimental