Journal article
An Open, Parallel, Randomized, Comparative, Multicenter Study to Evaluate the Cost-Effectiveness, Performance, Tolerance, and Safety of a Silver-Containing Soft Silicone Foam Dressing (Intervention) vs Silver Sulfadiazine Cream
Journal of burn care & research, v 32(6), pp 617-626
01 Nov 2011
PMID: 21979855
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An open, parallel, randomized, comparative, multicenter study was implemented to evaluate the cost-effectiveness, performance, tolerance, and safety of a silver-containing soft silicone foam dressing (Mepilex Ag) vs silver sulfadiazine cream (control) in the treatment of partial-thickness thermal burns. Individuals aged 5 years and older with partial-thickness thermal burns (2.5-20% BSA) were randomized into two groups and treated with the trial products for 21 days or until healed, whichever occurred first. Data were obtained and analyzed on cost (direct and indirect), healing rates, pain, comfort, ease of product use, and adverse events. A total of 101 subjects were recruited. There were no significant differences in burn area profiles within the groups. The cost of dressing-related analgesia was lower in the intervention group (P = .03) as was the cost of background analgesia (P = .07). The mean total cost of treatment was $309 vs $513 in the control (P < .001). The average cost-effectiveness per treatment regime was $381 lower in the intervention product, producing an incremental cost-effectiveness ratio of $1688 in favor of the soft silicone foam dressing. Mean healing rates were 71.7 vs 60.8% at final visit, and the number of dressing changes were 2.2 vs 12.4 in the treatment and control groups, respectively. Subjects reported significantly less pain at application (P = .02) and during wear (P = .048) of the Mepilex Ag dressing in the acute stages of wound healing. Clinicians reported the intervention dressing was significantly easier to use (P = .03) and flexible (P = .04). Both treatments were well tolerated; however, the total incidence of adverse events was higher in the control group. The silver-containing soft silicone foam dressing was as effective in the treatment of patients as the standard care (silver sulfadiazine). In addition, the group of patients treated with the soft silicone foam dressing demonstrated decreased pain and lower costs associated with treatment. (J Burn Care Res 2011;32:617-626)
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Details
- Title
- An Open, Parallel, Randomized, Comparative, Multicenter Study to Evaluate the Cost-Effectiveness, Performance, Tolerance, and Safety of a Silver-Containing Soft Silicone Foam Dressing (Intervention) vs Silver Sulfadiazine Cream
- Creators
- Paul Silverstein - Paul Silverstein Burn Ctr, Oklahoma City, OK 73116 USADavid Heimbach - Harborview Medical CenterHerbert Meites - Paul Silverstein Burn Ctr, Oklahoma City, OK 73116 USABarbara Latenser - Urban Institute (Germany)David Mozingo - UF Health Shands HospitalFred Mullins - Joseph M. Still Research FoundationWarren Garner - University of Southern CaliforniaJoseph Turkowski - Presbyterian HospitalJeffrey Shupp - MedStar Washington Hospital CenterPaul Glat - St. Christopher's Hospital for ChildrenGary Purdue - SW Reg Burn Ctr, Dallas, TX USA
- Publication Details
- Journal of burn care & research, v 32(6), pp 617-626
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Grant note
- Molnlycke Health Care
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000296769100011
- Scopus ID
- 2-s2.0-81155139570
- Other Identifier
- 991021838605504721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Critical Care Medicine
- Dermatology
- Surgery